Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases
Literature Information
Publication Date
2019-05-30
DOI
10.1039/C9OB01089K
Impact Factor
3.876
Authors
Kun Huang, Fabio Parmeggiani, Helene Ledru, Kristian Hollingsworth, Jordi Mas Pons, Andrea Marchesi, Peter Both, Ashley P. Mattey, Edward Pallister, Gregory S. Bulmer, Jolanda M. van Munster, W. Bruce Turnbull, M. Carmen Galan, Sabine L. Flitsch
View Original
Abstract
Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial β1,4-galactosyltransferases to catalyse the transgalactosylation from lactose to N-acetylglucosamine to form N-acetyllactosamine in the presence of UDP. The process is demonstrated by the preparative scale synthesis of pNP-β-LacNAc from lactose using β1,4-galactosyltransferase NmLgtB-B as the only biocatalyst.
Related Literature
Phase transition kinetics and surface binding states of methylammonium lead iodide perovskite
G. Rajendra Kumar, A. Dennyson Savariraj, S. N. Karthick, S. Selvam, B. Balamuralitharan, Hee-Je Kim, K. K. Viswanathan, M. Vijaykumar
2016-02-09
Paper
DOI: 10.1039/C5CP06232B
(Ti/Zr,N) codoped hematite for enhancing the photoelectrochemical activity of water splitting
Song Li, Gaowu Qin
2015-07-20
Paper
DOI: 10.1039/C5CP01489A
An olive-shaped SnO2 nanocrystal-based low concentration H2S gas sensor with high sensitivity and selectivity
Jun Hu, Junchen Chen, Meiying Ge, Jing Lu, Zhi Yang
2015-07-08
Paper
DOI: 10.1039/C5CP02854J
Soft X-ray absorption spectroscopy of Ar2 and ArNe dimers and small Ar clusters
Ghazal Jabbari, Tsveta Miteva, Vasili Stumpf, Kirill Gokhberg, Patrick O'Keeffe, Alessandra Ciavardini, Paola Bolognesi, Marcello Coreno, Lorenzo Avaldi, Elham Keshavarz, Maryam Ghandehari, Manijeh Tozihi, Carlo Callegari, Michele Alagia, Antti Kivimäki, Robert Richter
2015-07-22
Paper
DOI: 10.1039/C5CP03276H
Al atom on MoO3(010) surface: adsorption and penetration using density functional theory
Hong-Zhang Wu, Sateesh Bandaru, Da Wang, Jin Liu, Zhenling Wang, Li-Li Li
2016-02-10
Paper
DOI: 10.1039/C5CP07440A
An adaptive quantum mechanics/molecular mechanics method for the infrared spectrum of water: incorporation of the quantum effect between solute and solvent
Hiroshi C. Watanabe, Misa Banno, Minoru Sakurai
2016-02-08
Paper
DOI: 10.1039/C5CP07136D
Progress in the theory of electrostatic interactions between charged particles
Eric B. Lindgren, Ho-Kei Chan, Anthony J. Stace, Elena Besley
2016-01-25
Perspective
DOI: 10.1039/C5CP07709E
Reaction kinetics for the solid state synthesis of the AlH3/MgCl2 nano-composite by mechanical milling
C. W. Duan, L. X. Hu, Y. Sun, H. P. Zhou, H. Yu
2015-07-28
Paper
DOI: 10.1039/C5CP03768A
Tunable conduction type of solution-processed germanium nanoparticle based field effect transistors and their inverter integration
Zeynep Meric, Christian Mehringer, Nicolas Karpstein, Michael P. M. Jank, Wolfgang Peukert
2015-08-04
Paper
DOI: 10.1039/C5CP03321G
You might also like
Compound Q&A
What is 1-(2,4,6-Trifluorophenyl)ethanol (CAS: 1250113-83-7)?
1-(2,4,6-Trifluorophenyl)ethanol is an organic compound with the CAS number 1250...
1250113-83-71-(2,4,6-Trifluoroph...
Compound Q&A
Is 1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) safe?
1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) is ...
919111-34-51-(2,4-Dimethoxybenz...
Compound Q&A
What are the physical and chemical properties of (7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one (CAS: 51419-51-3)?
(7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one is a crystal...
51419-51-3(7S,15R)-6β,15-Diace...
Compound Q&A
What regulatory guidelines apply to rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3618-04-0)?
The compound rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3...
3618-04-0rac-ethyl (1r,4r)-4-...
Compound Q&A
What is the market or research trend for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3)?
The market for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3) is cur...
175135-62-32-(2,4-Difluoropheno...
Compound Q&A
What are the main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9)?
The main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9) include research in ...
157-03-96-Diazo-5-oxo-L-norl...
Compound Q&A
What precautions should be taken when handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5)?
When handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5), i...
173308-19-52-Aminoethyl-mono-am...
Compound Q&A
How is 5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) typically synthesized?
5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) can be synthesi...
178488-37-45-Methylimidazo[1,2-...
Compound Q&A
Are there alternatives to 2,4,6-Trihydroxyisophthalaldehyde (CAS: 4396-13-8) in synthesis?
There are alternative reagents that can be used in the synthesis of 2,4,6-Trihyd...
4396-13-82,4,6-Trihydroxyisop...
Compound Q&A
What is (2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid (CAS: 179461-52-0)?
(2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid is a chemical compound wi...
179461-52-0(2Z)-3-(5-Fluoro-1H-...
Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
(R)-2-amino-3-(benzyloxy)propan-1-ol hydrochloride
CAS Number:
58577-95-0
Molecular Formula:
C10H16ClNO2
![Imidazo[1,5-a]pyrazine structure](https://static.chemtradehub.com/structs/274/274-49-7-d749.webp "Imidazo[1,5-a]pyrazine structure")
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.