A controlled and versatile NCA polymerization method for the synthesis of polypeptides‡
Literature Information
Publication Date
2013-04-08
DOI
10.1039/C3PY00347G
Impact Factor
5.582
Authors
Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz, María J. Vicent
View Original
Abstract
A versatile and simple methodology for the preparation of well-defined polyglutamate nanocarriers is described. For the first time ammonium salts with non-nucleophilic tetrafluoroborate anions are used as initiators for the ring opening polymerization of α-N-carboxyanhydrides (NCAs) allowing a multigram scale polyglutamate synthesis with defined molecular weight (up to 800 units), low polydispersity (<1.2), controlled chain end functionality and adequate stereoselectivity and absence of any trace of toxic impurity to allow biomedical applications.
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Polymer Chemistry
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