Synthesis of vicinal dideoxy-difluorinated galactoses
Literature Information
Julien Malassis, Jean-Baptiste Vendeville, Qui-Hien Nguyen, Marie Boujon, Quentin Gaignard-Gaillard, Mark Light, Bruno Linclau
Fluorinated carbohydrates have been employed as probes for fundamental studies of protein–carbohydrate interactions, but also in the development of mechanism-based enzyme inhibitors. There is a continuing demand for novel fluorinated carbohydrate probes. Whereas most examples so far involved monodeoxyfluorinated sugars, multiply deoxyfluorinated sugars have gained much interest. Here we report the synthesis and characterisation of novel vicinal dideoxy-difluorinated D-galactoses with fluorination at the 3,4-positions, and at the 2,3-positions, the latter in both the pyranose and furanose forms. This includes a successful pyranose-into-furanose isomerisation protocol.
Related Literature
Nucleophilic thiol-Michael chemistry and hyperbranched (co)polymers: synthesis and ring-opening metathesis (co)polymerization of novel difunctional exo-7-oxanorbornenes with in situ inimer formation
Meina Liu, Beng Hoon Tan, Robert P. Burford, Andrew B. Lowe
DOI: 10.1039/C3PY00110E
New insights into radical and cationic polymerizations upon visible light exposure: role of novel photoinitiator systems based on the pyrene chromophore
Mohamad-Ali Tehfe, Frédéric Dumur, Emmanuel Contal, Bernadette Graff, Fabrice Morlet-Savary, Didier Gigmes, Jean-Pierre Fouassier, Jacques Lalevée
DOI: 10.1039/C2PY20950K
Using reversibility of the dynamic covalent bond to create porosity in highly ordered polymer thin films under mild conditions and nano-pore functionalization in the gas phase
Jingyi Rao, Anzar Khan
DOI: 10.1039/C3PY00200D
UV- and NIR-responsive polymeric nanomedicines for on-demand drug delivery
Gang Liu, Wei Liu, Chang-Ming Dong
DOI: 10.1039/C3PY21121E
SET-LRP synthesis of novel polyallene-based well-defined amphiphilic graft copolymers in acetone
Guolin Lu, Yongjun Li, Hao Guo, Weiyuan Du, Xiaoyu Huang
DOI: 10.1039/C3PY00145H
Living radical polymerization of vinyl acetate and methyl acrylate mediated by Co(Salen*) complexes
Chei-Ming Liao, Ching-Chun Hsu, Fu-Sheng Wang, Bradford B. Wayland, Chi-How Peng
DOI: 10.1039/C3PY00282A
Hybrid materials consisting of an all-conjugated polythiophene backbone and grafted hydrophilic poly(ethylene glycol) chains
Luminita Cianga, Luis J. del Valle, Ioan Cianga
DOI: 10.1039/C3PY00029J
Atom transfer radical polymerization as a tool for making poly(N-acryloylglycinamide) with molar mass independent UCST-type transitions in water and electrolytes
Fangyao Liu, Jan Seuring, Seema Agarwal
DOI: 10.1039/C3PY00222E
A novel polytriazole-based organogel formed by the effects of copper ions
Yujing Li, Liqiang Wan, Hao Zhou, Farong Huang, Lei Du
DOI: 10.1039/C3PY00227F
You might also like
What is 1-(2,4,6-Trifluorophenyl)ethanol (CAS: 1250113-83-7)?
1-(2,4,6-Trifluorophenyl)ethanol is an organic compound with the CAS number 1250...
Is 1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) safe?
1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) is ...
What are the physical and chemical properties of (7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one (CAS: 51419-51-3)?
(7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one is a crystal...
What regulatory guidelines apply to rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3618-04-0)?
The compound rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3...
What is the market or research trend for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3)?
The market for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3) is cur...
What are the main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9)?
The main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9) include research in ...
What precautions should be taken when handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5)?
When handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5), i...
How is 5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) typically synthesized?
5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) can be synthesi...
Are there alternatives to 2,4,6-Trihydroxyisophthalaldehyde (CAS: 4396-13-8) in synthesis?
There are alternative reagents that can be used in the synthesis of 2,4,6-Trihyd...
What is (2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid (CAS: 179461-52-0)?
(2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid is a chemical compound wi...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.










![5-Bromo-1H-pyrrolo[2,3-b]pyridine structure 5-Bromo-1H-pyrrolo[2,3-b]pyridine structure](https://static.chemtradehub.com/structs/183/183208-35-7-2d72.webp)


