Copper and palladium-catalyzed sequential reactions: one-pot synthesis of isoindolo[2,1-b]isoquinolin-7(5H)-ones
Literature Information
Hitesh Kumar Saini, Shiv Dhiman, Nitesh Kumar Nandwana, Rangan Krishnan, Anil Kumar
A highly efficient protocol has been developed for the synthesis of diversely substituted isoindolo[2,1-b]isoquinolin-7(5H)-ones through sequential Cu(II)-catalyzed Sonogashira coupling, intramolecular hydroamidation followed by palladium-catalyzed ligand-free Heck reaction. Good to excellent yields (41–94%) were observed with excellent substrate scope and functional group tolerance. The developed method represents a practical strategy for the construction of bioactive isoindolo[2,1-b]isoquinolin-7(5H)-ones.
Related Literature
(Ti/Zr,N) codoped hematite for enhancing the photoelectrochemical activity of water splitting
Song Li, Gaowu Qin
DOI: 10.1039/C5CP01489A
Amorphous SiO2 surface models: energetics of the dehydroxylation process, strain, ab initio atomistic thermodynamics and IR spectroscopic signatures
DOI: 10.1039/C6CP00602G
Thermodynamics of Fe3O4–Co3O4 and Fe3O4–Mn3O4 spinel solid solutions at the bulk and nanoscale
Sulata K. Sahu, Baiyu Huang, Kristina Lilova, Brian F. Woodfield, Alexandra Navrotsky
DOI: 10.1039/C5CP02972D
Local environments of boron heteroatoms in non-crystalline layered borosilicates
Mounesha N. Garaga, Ming-Feng Hsieh, Zalfa Nour, Michael Deschamps, Dominique Massiot, Bradley F. Chmelka, Sylvian Cadars
DOI: 10.1039/C5CP03448E
Effects of constituent ions of a phosphonium-based ionic liquid on molecular organization of H2O as probed by 1-propanol: tetrabutylphosphonium and trifluoroacetate ions
Takeshi Morita, Kumiko Miki, Ayako Nitta, Hiroyo Ohgi, Peter Westh
DOI: 10.1039/C5CP02329G
Ultraviolet-light-driven doping modulation in chemical vapor deposition grown graphene
M. W. Iqbal, M. F. Khan, Jonghwa Eom
DOI: 10.1039/C5CP02159F
Structural transition upon hydrogenation of B20 at different charge states: from tubular to disk-like, and to cage-like
Bing Bai, Hui Bai
DOI: 10.1039/C5CP07731A
Binding properties of pendimethalin herbicide to DNA: multispectroscopic and molecular docking approaches
Irshad Ahmad, Ajaz Ahmad, Masood Ahmad
DOI: 10.1039/C5CP07351K
Partitioning of mobile ions between ion exchange polymers and aqueous salt solutions: importance of counter-ion condensation
Jovan Kamcev, Michele Galizia, Francesco M. Benedetti, Eui-Soung Jang, Donald R. Paul, Benny D. Freeman, Gerald S. Manning
DOI: 10.1039/C5CP06747B
Unusual Mn coordination and redox chemistry in the high capacity borate cathode Li7Mn(BO3)3
Christopher Eames, Stephen M. Wood, M. Saiful Islam
DOI: 10.1039/C5CP02711J
You might also like
What is 1-(2,4,6-Trifluorophenyl)ethanol (CAS: 1250113-83-7)?
1-(2,4,6-Trifluorophenyl)ethanol is an organic compound with the CAS number 1250...
Is 1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) safe?
1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) is ...
What are the physical and chemical properties of (7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one (CAS: 51419-51-3)?
(7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one is a crystal...
What regulatory guidelines apply to rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3618-04-0)?
The compound rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3...
What is the market or research trend for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3)?
The market for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3) is cur...
What are the main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9)?
The main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9) include research in ...
What precautions should be taken when handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5)?
When handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5), i...
How is 5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) typically synthesized?
5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) can be synthesi...
Are there alternatives to 2,4,6-Trihydroxyisophthalaldehyde (CAS: 4396-13-8) in synthesis?
There are alternative reagents that can be used in the synthesis of 2,4,6-Trihyd...
What is (2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid (CAS: 179461-52-0)?
(2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid is a chemical compound wi...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.










![2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole structure 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole structure](https://static.chemtradehub.com/structs/122/1226781-80-1-09d5.webp)


