![4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile structure](https://static.chemtradehub.com/structs/103/1036629-63-6-2172.webp "4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile structure")
4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile
CAS Number:
1036629-63-6
Molecular Formula:
C15H10F3NO2
Competitive adsorption on gold nanoparticles for human papillomavirus 16 L1 protein detection by LDI-MS
Literature Information
Publication Date
2019-09-29
DOI
10.1039/C9AN01612K
Impact Factor
4.616
Authors
Jing Han, Zhihua Wang, Lihui Yin, Wei Zhang, You Peng, Zongxiu Nie
View Original
Abstract
The detection of the HPV L1 protein provides information about the infection status of the virus, reflects the replication status of the HPV virus in cervical cells, and helps understand the regression and progress of cervical lesions. Herein, we report a novel laser desorption ionization mass spectrometry (LDI MS) method for the sensitive detection of the HPV 16 L1 protein, based on non-covalent competitive adsorption between the HPV 16 L1 aptamer and melamine on gold nanoparticles (AuNPs). The intensity of the MS signal corresponding to the mass tag shows a linear relationship with the HPV 16 L1 concentration in the range 2–80 ng mL−1, with a limit of detection (LOD) of 58.8 pg mL−1. Using this method, the HPV 16 L1 protein is quantitatively analyzed in both clinical and vaccine samples. The described method is simple and has high sensitivity and good reliability.
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Source Journal
Analyst
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
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