A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection

Literature Information

Publication Date 2019-09-09
DOI 10.1039/C9AN01568J
Impact Factor 4.616
Authors

Shuang Liu, Chen Xin, Xiaoxiao Yu, Zhenbo Ding, Shufeng Liu


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Abstract

A catalytic DNA circuit was ingeniously engineered to harness the cleavage of a nicking endonuclease on a triple-stranded duplex DNA probe, autonomously actuating a successive enzyme-powered DNA machine for one-step, isothermal, and autocatalytic nucleic acid analysis. The detection performance could be tuned with or without the use of enzymes.

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