Quantum-dot-encapsulated core–shell barcode particles from droplet microfluidics

Literature Information

Publication Date 2018-07-19
DOI 10.1039/C8TB00946E
Impact Factor 6.331
Authors

Feika Bian, Huan Wang, Lingyu Sun, Yuxiao Liu, Yuanjin Zhao


View Original

Abstract

The development of robust quantum dot (QD) barcode particles with specific compositions and simple identification is important to meet the demand for high-throughput assays. Here, we present a multiple-inner phase channel capillary microfluidic approach to generate novel QD-encapsulated core–shell barcode particles with distinctive features for multiplexing analysis. By using different QD dispersed polyethylene glycol diacrylate (PEGDA) solutions as the inner phases, the particles were endowed with hydrogel locked QD cores, which could maintain the dispersed status and provide distinctive identification for the particles. The shells of the barcode particles were silica nanoparticle-dispersed ethoxylated trimethylolpropane triacrylate (ETPTA) resin, which could not only improve the stability and biocompatibility of QDs, but also provide functional groups for immobilization of biomolecules due to the assembling of the silica nanoparticles on their surfaces. Due to the advanced emulsification capability of the capillary microfluidic device, double emulsion templates with multiple inner droplet phases and their resultant multicomponent QD-encapsulated core–shell barcode particles could be continually generated. These particles showed remarkable spectral coding capacity in practice, which make them ideal for biomedical applications.

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Journal of Materials Chemistry B
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Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.

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