Integrating reactive distillation with continuous flow processing

Literature Information

Publication Date 2018-11-30
DOI 10.1039/C8RE00217G
Impact Factor 4.239
Authors

Marcus Baumann


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Abstract

A continuous flow platform has been developed that integrates reactive distillation with modern flow reactor technology. This has been applied to the successful flow synthesis of a series of tetrahydroquinolines generated through an InCl3-catalysed Povarov reaction between different aryl imines and cyclopentadiene that was generated by a continuous distillation from its dimeric precursor via a thermal retro Diels–Alder reaction. The developed continuous process represents a robust approach to these important heterocyclic entities which were prepared on the gram scale within less than one hour.

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Source Journal

Reaction Chemistry & Engineering

Reaction Chemistry & Engineering
CiteScore: 0
Self-citation Rate: 8.8%
Articles per Year: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

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