2,5,8,11,14,17,20,23,26,29,32-Undecaoxatetratriacontan-34-amine
CAS Number:
854601-60-8
Molecular Formula:
C23H49NO11
Scale-up of N-alkylation reaction using phase-transfer catalysis with integrated separation in flow
Literature Information
Publication Date
2018-11-15
DOI
10.1039/C8RE00203G
Impact Factor
4.239
Authors
María José Nieves-Remacha, Myriam Torres, María Ruiz-Abad, Juan A. Rincón, Graham R. Cumming, Pablo Garcia-Losada
View Original
Abstract
A continuous phase-transfer catalysis process for N-alkylation integrated with separation was developed. This approach circumvents the heat and mass transfer limitations encountered in batch scale-up, enabling a safer process and yielding a higher-quality product. Two continuous flow approaches are analyzed: a) an automated fill–empty reactor with an integrated gravity separator and b) a tubular flow reactor with an inline membrane separator. The fill–empty platform enabled the direct technology transfer from batch, achieving conversions >99% (by HPLC) and purities >90%. The tubular flow reactor allowed the reduction of the base solution requirements, yielding conversions of 91% and purities >88%. Both the setups provide a small process footprint with downstream integrated separation. The on-demand scale-up was efficiently and safely demonstrated using the fill–empty approach for the production of various substrates at the multigram scale.
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Source Journal
Reaction Chemistry & Engineering
CiteScore:
0
Self-citation Rate:
8.8%
Articles per Year:
284
Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.
Recommended Compounds
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trans,trans-4-n-Propyl-4-[4-(trifluoromethoxy)phenyl]bicyclohexyl
CAS Number:
133937-72-1
Molecular Formula:
C22H31F3O
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5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine
CAS Number:
865362-74-9
Molecular Formula:
C18H13N7
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(1S,4aR,5R,7S,7aS)-1-(beta-D-Glucopyranosyloxy)-5-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl alpha-D-galactopyranoside
CAS Number:
81720-07-2
Molecular Formula:
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