Dirhodium(ii)-catalyzed ortho C–H amination of sterically congested N,N-dialkylanilines

Literature Information

Publication Date 2018-09-12
DOI 10.1039/C8OB01974F
Impact Factor 3.876
Authors

Motoki Ito, Tomoya Nakagawa, Kazuhiro Higuchi, Shigeo Sugiyama


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Abstract

Dirhodium(II)-catalyzed ortho C–H amination of N,N-dialkylanilines has been developed. Sterically congested 1,2-diaminobenzenes were obtained in high yields with excellent chemo- and regioselectivities from para-substituted anilines and even from para-unsubstituted anilines. The ortho selectivity observed was rationalized in terms of the interaction between the dialkylamino group and a Rh(II)–nitrene intermediate.

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