Darzens reaction of thioisatins and sulfonium salts: approach to the synthesis of thiochromenone derivatives with anticancer potency
Literature Information
Jinhui Shen, Yang Yang, Xiaoli Hou, Wenlei Zeng, Aimin Yu, Xiaowei Zhao, Xiangtai Meng
A new Darzens reaction of thioisatins and sulfonium salts has, for the first time, been reported. This reaction allows efficient access to thiochromenone derivatives in good to excellent yields under mild reaction conditions. The substrate scope includes both electron-withdrawing and electron-donating groups on both the thioisatins and sulfonium salts. Moreover, some of the synthesized thiochromenone derivatives have been found to show potent anticancer activities against six different cancer cell lines using the methylthiazoltetrazolium (MTT) assay.
Related Literature
The state of absorbed hydrogen in the structure of reduced copper chromite from the vibration spectra
Galina N. Kustova, Hervé Jobic, Tamara M. Yurieva, Georgii A. Filonenko, Lyudmila M. Plyasova
DOI: 10.1039/B821381J
Multiphoton ionization/dissociation dynamics of formyl fluoride by velocity mapping ion imaging
Fengyan Wang, Yongwei Zhang, Hua Wang, Jie Liu, Bo Jiang, Xiuyan Wang, Xueming Yang
DOI: 10.1039/B903688A
Mesomorphic properties of the neat enantiomers of a chiral pyramidic liquid crystal
Zeev Luz, Raphy Poupko, Ellen J. Wachtel, Herbert Zimmermann
DOI: 10.1039/B908029P
How water links to cis and trans peptidic groups: the rotational spectrum of N-methylformamide–water
Walther Caminati, Juan Carlos López, Susana Blanco, Santiago Mata, Josè Luis Alonso
DOI: 10.1039/C003649H
Reactivity of poly-alcohols towards OH, NO3 and SO4− in aqueous solution
Dirk Hoffmann, Barbara Weigert, Paolo Barzaghi, Hartmut Herrmann
DOI: 10.1039/B908459B
Spin-component scaled coupled-clusters singles and doubles optimized towards calculation of noncovalent interactions
Jan Řezáč
DOI: 10.1039/C0CP00158A
Cyanide leaching of Au/CeO2: highly active gold clusters for 1,3-butadiene hydrogenation
Y. Guan, E. J. M. Hensen
DOI: 10.1039/B909487C
Influence of Si distribution in framework of SAPO-34 and its particle size on propylene selectivity and production rate for conversion of ethylene to propylene
Yasuyoshi Iwase, Ken Motokura, To-ru Koyama, Akimitsu Miyaji, Toshihide Baba
DOI: 10.1039/B911659A
You might also like
How should waste containing N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide (CAS: 898825-89-3) be handled?
Waste containing N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide (CAS: 898825-89-3...
How should N-(4-Biphenylyl)dibenzo[b,d]furan-4-amine (CAS: 1318338-47-4) be stored?
N-(4-Biphenylyl)dibenzo[b,d]furan-4-amine should be stored in a tightly sealed c...
What is the market or research trend for 3-Acetamido-5-amino-2,4,6-triiodobenzoic acid (CAS: 1713-07-1)?
The market for 3-Acetamido-5-amino-2,4,6-triiodobenzoic acid (CAS: 1713-07-1) is...
How should Benzyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-galactopyranoside (CAS: 61820-03-9) be stored?
Benzyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-galactopyranoside (CAS: 61820-03-9) ...
What regulatory guidelines apply to 2-Ethylpiperazine dihydrochloride (CAS: 438050-52-3)?
2-Ethylpiperazine dihydrochloride (CAS: 438050-52-3) is regulated under the Glob...
What regulatory guidelines apply to 1,1'-[1,3-Phenylenebis(methylene)]bis(3-methyl-1H-pyrrole-2,5-dione) (CAS: 119462-56-5)?
1,1'-[1,3-Phenylenebis(methylene)]bis(3-methyl-1H-pyrrole-2,5-dione) (CAS: 11946...
Are there alternatives to 5-Fluoro-2-(1-pyrrolidinyl)pyridine (CAS: 1287217-79-1) in synthesis?
Several alternatives can be used in the synthesis of 5-Fluoro-2-(1-pyrrolidinyl)...
What precautions should be taken when handling 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (CAS: 153631-19-7)?
Proper personal protective equipment (PPE) must be worn when handling this compo...
What precautions should be taken when handling 6-Bromoimidazo[1,2-a]pyridin-8-amine (CAS: 676371-00-9)?
When handling 6-Bromoimidazo[1,2-a]pyridin-8-amine, it is important to wear appr...
Are there alternatives to (2S,4R)-4-(4-Nitrobenzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS: 1049740-22-8) in synthesis?
Alternatives to (2S,4R)-4-(4-Nitrobenzyl)pyrrolidine-2-carboxylic acid hydrochlo...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.














