Metal-free photocatalyzed aerobic oxidative Csp3–H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones

Literature Information

Publication Date 2018-05-01
DOI 10.1039/C8OB00240A
Impact Factor 3.876
Authors

Youxiang He, Baorun Yan, Hua Tao, Yuan Zhang, Ying Li


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Abstract

A metal-free aerobic oxidative dehydrogenative coupling/annulation tandem reaction of glycine derivatives to 2,3-dihydrofuran is disclosed. This process involves the synergistic performance of organic-dye-mediated photoredox catalysis and acid catalysis. This reaction provides rapid and facile access to a series of valuable quinoline-fused lactones at room temperature under an air atmosphere. Moreover, the reaction could be performed on a 20 mmol scale, without obvious reduction of the yield.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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