Isolation and structural characterization of a titanacyclopropane as key intermediate in the double aryl Grignard addition to 2-(arylethynyl)pyridine derivatives
Literature Information
Publication Date
2018-02-05
DOI
10.1039/C8CC00478A
Impact Factor
6.222
Authors
Francesco Foschi, Torsten Roth, Markus Enders, Hubert Wadepohl, Eric Clot, Lutz H. Gade
View Original
Abstract
A titanacyclopropane species, which is a key reaction intermediate in the Ti(OiPr)4-mediated double aryl Grignard addition to 1,2-di(pyridin-2-yl)ethyne and related alkynes, was isolated and fully characterized. Based on this observation a one-pot synthesis of diarylated 1,2-di(pyridin-2-yl)ethanes and 2-(1,2,2-triarylvinyl)-pyridines was developed, including the tetraarylation of V-shaped 2,6-bis(arylethynyl)pyridines.
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Source Journal
Chemical Communications
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Recommended Compounds
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[2-(Benzyloxy)-3-bromo-5-methylphenyl]boronic acid
CAS Number:
870777-20-1
Molecular Formula:
C14H14BBrO3
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Sodium 6-amino-3-[(E)-{4-[(E)-(4-aminophenyl)diazenyl]-2-methoxy-5-methylphenyl}diazenyl]-4-hydroxy-2-naphthalenesulfonate
CAS Number:
2945-96-2
Molecular Formula:
C24H21N6NaO5S
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