Intramolecular aminocyanation of alkenes promoted by hypervalent iodine
Literature Information
Hang Shen, Qingfu Deng, Ruojuan Liu, Yangyang Feng, Congke Zheng
A transition metal-free and hypervalent iodine-promoted annulative aminocyanation of unactivated alkenes has been developed for the first time. This regioselective 5-exo-trig process provides a concise method to synthesize diversely substituted cyanated pyrrolidine, piperidine and indoline derivatives under mild reaction conditions with up to 80% yield, in which the cyanated position of the double bond is controlled by different hypervalent iodine regents.
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Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry














