[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne–azide cycloaddition

Literature Information

Publication Date 2017-11-15
DOI 10.1039/C7OB02532G
Impact Factor 3.876
Authors

Mehdi Boudjemeline, Christopher D. McNitt, Thomas A. Singleton, Vladimir V. Popik, Alexey P. Kostikov


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Abstract

A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [18F]oxadibenzocyclooctyne ([18F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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