A non-tight chemomechanical coupling model for force-dependence of movement dynamics of molecular motors

Literature Information

Publication Date 2018-01-17
DOI 10.1039/C7CP05557A
Impact Factor 3.676
Authors

Hong Chen


View Original

Abstract

Based on the available experimental evidence, we present a simple and general model to describe the movement dynamics of molecular motors that can move processively on their linear tracks by using the chemical energy derived from ATP hydrolysis. An important aspect of the model is the non-tight coupling between the ATP hydrolysis and mechanical stepping, in contrast to the prevailing models presented in the literature that assume the tight chemomechanical coupling. With kinesin as an example, based on the current model, we study in detail its movement dynamics under a backward load, reproducing well the diverse available single-molecule experimental data such as the forward to backward step ratio, velocity, dwell time, randomness, run length, etc., versus the load. Moreover, predicted results are provided on the force-dependence of the mean number of ATP molecules consumed per mechanical step. Additionally, the theoretical data for the dynamics of myosin-V obtained based on the model are also in good agreement with the available experimental data.

Related Literature

Thermodynamics of faceted palladium(–gold) nanoparticles supported on rutile titania nanorods studied using transmission electron microscopy

Nhat Tai Nguyen, Jaysen Nelayah, Damien Alloyeau, Guillaume Wang, Laurent Piccolo, Pavel Afanasiev, Christian Ricolleau

2018-04-05 Paper

DOI: 10.1039/C8CP00737C

The origin of absorptive features in the two-dimensional electronic spectra of rhodopsin

Marwa H. Farag, Thomas L. C. Jansen, Jasper Knoester

2018-04-18 Paper

DOI: 10.1039/C8CP00638E

Time-dependent changes in the growth of ultrathin ionic liquid films on Ag(111)

Matthias Lexow, Timo Talwar, Bettina S. J. Heller, Benjamin May, Radha G. Bhuin, Florian Maier, Hans-Peter Steinrück

2018-04-27 Paper

DOI: 10.1039/C8CP01411F

Mediating both valence and conduction bands of TiO2 by anionic dopants for visible- and infrared-light photocatalysis

Tingwei Chen, Guokui Liu, Fan Jin, Min Wei, Jin Feng, Yuchen Ma

2018-04-04 Paper

DOI: 10.1039/C8CP00895G

Oxidation behaviour of U3Si2: an experimental and first principles investigation

Ericmoore Jossou, Ubong Eduok, Nelson Y. Dzade, Barbara Szpunar, Jerzy A. Szpunar

2018-01-12 Paper

DOI: 10.1039/C7CP07154J

Patterned polyaniline encapsulated in titania nanotubes for electrochromism

Haiming Lv, Yi Wang, Lei Pan, Leipeng Zhang, Hangchuan Zhang, Lei Shang, Huiying Qu, Na Li, Jiupeng Zhao, Yao Li

2018-01-25 Paper

DOI: 10.1039/C7CP07617G

Halogen-like properties of the Al13 cluster mimicking astatine

B. Molina, J. R. Soto, J. J. Castro

2018-04-04 Communication

DOI: 10.1039/C8CP00494C

You might also like

155412-88-71-(3-Aminophenyl)-3-...
Compound Q&A

How should waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 19132-12-8) be handled?

Waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 191...

19132-12-81-(D-Ribofuranosyl)-...
Compound Q&A

What regulatory guidelines apply to 2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 2007919-81-3)?

2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 20079...

2007919-81-32-Methyl-2-propanyl ...
Compound Q&A

What is N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0)?

N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0) is a chemical compound with...

245056-66-0N-(4-Chloro-2-pyridi...
Compound Q&A

What is 5-Chloro-2-hydroxybenzoic acid (CAS: 321-14-2)?

5-Chloro-2-hydroxybenzoic acid, also known as 5-chlorosalicylic acid, is an arom...

321-14-25-Chloro-2-hydroxybe...
Compound Q&A

What precautions should be taken when handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6)?

When handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6), it is important to u...

1717-00-61,1-Dichloro-1-fluor...
Compound Q&A

What are the physical and chemical properties of Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (CAS: 281655-32-1)?

Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid is a white crystalline solid ...

281655-32-1Fmoc-(2S,3R)-3-pheny...
Compound Q&A

What are the main uses of 4-Amino-5-bromo-2-pyridinecarboxylic acid (CAS: 1363381-01-4)?

4-Amino-5-bromo-2-pyridinecarboxylic acid is primarily used as a precursor in th...

1363381-01-44-Amino-5-bromo-2-py...
1007881-98-2(S)-tert-butyl 2-((2...
Compound Q&A

What precautions should be taken when handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS: 688363-73-7)?

When handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one, use prop...

688363-73-78-bromo-2,2-dimethyl...

Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.