A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells

Literature Information

Publication Date 2017-10-26
DOI 10.1039/C7AN01336A
Impact Factor 4.616
Authors

Guoyu Jiang, Wenping Zhu, Qingqing Chen, Aiping Shi, Yongquan Wu, Guanxin Zhang, Xun Li, Yongdong Li, Xiaolin Fan, Jianguo Wang


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Abstract

An AIE based tetraphenylethylene derivative (TPPTPE) was synthesized for light-up sensing of ATP in aqueous solution. The measuring range for ATP can be tuned by varying the concentration of the TPPTPE. A one-step straightforward quantitative analysis of the ATP level in cell lysates can be realized using the TPPTPE. Moreover, the TPPTPE can be used for monitoring apyrase activity in aqueous solution and detecting ATP both in living cancer cell lines and in living normal cell lines.

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