![[(2R)-6,6-Dimethyl-2-morpholinyl]methanol hydrochloride (1:1) structure](https://static.chemtradehub.com/structs/141/1416444-88-6-e06a.webp "[(2R)-6,6-Dimethyl-2-morpholinyl]methanol hydrochloride (1:1) structure")
[(2R)-6,6-Dimethyl-2-morpholinyl]methanol hydrochloride (1:1)
CAS Number:
1416444-88-6
Molecular Formula:
C7H16ClNO2
A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion
Literature Information
Publication Date
2016-11-15
DOI
10.1039/C6PY01418F
Impact Factor
5.582
Authors
Felicity Heath, Amy Newman, Chiara Clementi, Gianfranco Pasut, Hong Lin, Gary J. Stephens, Benjamin J. Whalley, Helen M. I. Osborn, Francesca Greco
View Original
Abstract
A PEG–haloperidol conjugate containing a non-biodegradable linker was synthesised. Incubation with rat plasma demonstrated excellent linker stability, and competition radioligand binding assays demonstrated retained binding to the D2-receptor. In silico studies predicted that the conjugate will not cross the blood–brain barrier (BBB), thus potentially restricting haloperidol action to one side of the BBB.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
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8-Bromo-6-fluoro[1,2,4]triazolo[1,5-a]pyridin-2-amine
CAS Number:
1257705-51-3
Molecular Formula:
C6H4BrFN4
Ethyl 2,4-bis(trifluoromethyl)-5-pyrimidinecarboxylate
CAS Number:
188781-15-9
Molecular Formula:
C9H6F6N2O2
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