A facile one-step folic acid modified partially oxidized graphene for high sensitivity tumor cell sensing
Literature Information
Publication Date
2016-05-27
DOI
10.1039/C6AN00778C
Impact Factor
4.616
Authors
Wenyu Gao, Zongxu Shen, Hao Wu, Yuehui Ma, Weijun Guan, Songmei Wu, Yu Yu, Kejian Ding
View Original
Abstract
A highly sensitive and selective tumor cell sensor based on partially oxidized graphene (POG) and folate acid (FA) composite was constructed. The POG was prepared through a modified Hummers method and characterized by means of Raman spectroscopy, X-ray photoelectron spectroscopy, cyclic voltammetry, atomic force microscopy and transmission electron microscopy. The as-prepared POG exhibited the advantages of high electrochemical activity and a good capacity of linking amine derivatives. Using a facile one step reaction, the FA-modified POG was endowed with a more sensitive response to folate-expressing tumor cells than those sensors constructed by the two-step reaction, as well as high selectivity, good reproducibility and long-term stability.
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Analyst
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5.6%
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
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