Electrochromic sensing platform based on steric hindrance effects for CEA detection

Literature Information

Publication Date 2016-04-26
DOI 10.1039/C6AN00675B
Impact Factor 4.616
Authors

Yong Xia, Jing Li, Erkang Wang


View Original

Abstract

In this work, an electrochromic sensing platform with prussian blue (PB) as the indicator was proposed for signaling carcinoembryonic antigen (CEA) using the bipolar electrode (BPE) system. The CEA aptamer was pre-anchored on the anode pole of the BPE for capturing CEA through strong binding affinity. The presence of CEA induced the increase of steric hindrance and led to lower electrochemical currents. Due to the quantitative relationship between the two reactions occurring at both ends of the BPE, the amount of deposited PB in situ can be used as an indicator for reporting target protein concentration. Using CEA concentration in normal human serum as a reference (5 ng mL−1), this electrochromic sensing platform can be used for distinguishing persons with cancer from normal humans easily and quickly, which is very important for subsequent treatment of patients. This novel electrochromic platform has great selectivity for target tumor proteins and provides a fast, visual method for CEA detection. Finally, the proposed biosensor can be applied to detect CEA in human serum, which holds great potential for point-of-care diagnostics combined with the advantage of the closed BPE system.

Related Literature

Fe(iii)-carboxythiolate layered metal–organic frameworks with interest as active materials for rechargeable alkali-ion batteries

Nusik Gedikoglu, Pablo Salcedo-Abraira, Nathalie Guillou, Nicolas Dupré, Christophe Payen, Philippe Poizot, Thomas Devic

2023-10-20 Paper

DOI: 10.1039/D3TA05353A

Carrier density and delocalization signatures in doped carbon nanotubes from quantitative magnetic resonance

M. Alejandra Hermosilla-Palacios, Marissa Martinez, Evan A. Doud, Tobias Hertel, Alexander M. Spokoyny, Sofie Cambré, Wim Wenseleers, Yong-Hyun Kim, Andrew J. Ferguson, Jeffrey L. Blackburn

2023-11-22 Communication

DOI: 10.1039/D3NH00480E

Phonon vortices at heavy impurities in two-dimensional materials

De-Liang Bao, Mingquan Xu, Ao-Wen Li, Wu Zhou

2023-12-07 Communication

DOI: 10.1039/D3NH00433C

A selenoureido-iminoglycolipid transported by zeolitic-imidazolate framework nanoparticles: a novel antioxidant therapeutic approach

Fátima Guerrero, Andrés Carmona, Victoria Vidal, Ana Franco, Alejandro Martín-Malo, Elena M. Sánchez-Fernández, Carolina Carrillo-Carrión

2023-10-06 Communication

DOI: 10.1039/D3NH00363A

The intrinsic activity descriptor of TM-N3-C single-atom catalysts for electrochemical CO2 reduction: a DFT study

Linmeng Wang, Zhiyuan Liu, Rushuo Li, Ping Yang, Wei Wang, Xiangdong Xue, Shihao Feng, Lingjing Yu, Ge Wang

2023-10-27 Paper

DOI: 10.1039/D3TA04806C

Dual carbon engineering enabling 1T/2H MoS2 with ultrastable potassium ion storage performance

Rong Hu, Yanqi Tong, Jinling Yin, Junxiong Wu, Jing Zhao, Dianxue Cao, Guiling Wang, Kai Zhu

2023-12-20 Communication

DOI: 10.1039/D3NH00404J

Self-organized defect-rich RuMOx epitaxial layers (M = Mn, Fe, Co, Ni, Cu) for catalytic applications

Risa Ichihashi, Yuta Yamamoto, Kyoichi Sawabe

2023-10-12 Paper

DOI: 10.1039/D3TA05078E

Looking back at 2023

2023-12-11 Editorial

DOI: 10.1039/D3NH90059B

You might also like

Compound Q&A

What precautions should be taken when handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2)?

When handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2), it is importan...

16712-20-2Lithium chloride hyd...
Compound Q&A

Is 4-(4H-1,2,4-Triazol-4-yl)piperidine (CAS: 690261-92-8) safe?

4-(4H-1,2,4-Triazol-4-yl)piperidine is generally considered safe for use in phar...

690261-92-84-(4H-1,2,4-Triazol-...
Compound Q&A

How should waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) be handled?

Waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) should be collecte...

16733-85-01,3-Thiazole-2-carbo...
Compound Q&A

What regulatory guidelines apply to 5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3)?

5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3) is subject to regulat...

934175-58-35-(Difluoromethyl)-2...
Compound Q&A

How is Methyl 3-acetamido-2-thiophenecarboxylate (CAS: 22288-79-5) typically synthesized?

Methyl 3-acetamido-2-thiophenecarboxylate can be synthesized by the reaction of ...

22288-79-5Methyl 3-acetamido-2...
Compound Q&A

What is 4-Isoquinolinecarbonitrile (CAS: 34846-65-6)?

4-Isoquinolinecarbonitrile is a chemical compound with the CAS number 34846-65-6...

34846-65-64-Isoquinolinecarbon...
Compound Q&A

How should Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) be stored?

Store Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) in a cool, dry p...

877309-59-6Methyl 1H-1,2,3-tria...
Compound Q&A

What regulatory guidelines apply to 6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8)?

6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8) is subject to the...

1160791-13-86-Bromo[1,3]thiazolo...
Compound Q&A

Is (2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) safe?

(2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) ...

23651-95-8(2S,3S)-2-Ammonio-3-...
Compound Q&A

What are the physical and chemical properties of 7-bromo-3-methyl-3,4-dihydroquinazolin-4-one (CAS: 1293987-84-4)?

7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one is a solid with a crystalline form....

1293987-84-47-bromo-3-methyl-3,4...

Source Journal

Analyst

Analyst
CiteScore: 7.8
Self-citation Rate: 5.6%
Articles per Year: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.