N-Heterocyclic carbene-catalyzed [4 + 2] annulation of α,β-unsaturated carboxylic acids: enantioselective synthesis of dihydropyridinones and spirocyclic oxindolodihydropyridinones
Literature Information
Publication Date
2015-11-16
DOI
10.1039/C5QO00301F
Impact Factor
5.281
Authors
Wen-Qiang Jia, Han-Ming Zhang, Chun-Lin Zhang, Zhong-Hua Gao, Song Ye
View Original
Abstract
The N-heterocyclic carbene-catalyzed generation of dienoate from α,β-unsaturated carboxylic acid via the in situ formed mixed anhydride, and the following [4 + 2] annulation with hydrazones and isatin-derived imines was developed, affording the corresponding dihydropyridinones and spirocyclic oxindolodihydropyridinones, respectively, in moderate to good yields with good to excellent enantioselectivities.
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Organic Chemistry Frontiers
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