Synthesis of Passerini adducts from aldehydes and isocyanides under the auxiliary of water
Literature Information
Publication Date
2015-07-23
DOI
10.1039/C5QO00202H
Impact Factor
5.281
Authors
Ming Li, Bin Qiu, Xiang-Jing Kong, Li-Rong Wen
View Original
Abstract
An efficient protocol for the synthesis of the Passerini adducts α-acyloxycarboxamides from aldehydes, isocyanides and water in a molecular ratio of 3 : 1 : 3 was described. The possible mechanism for the reaction was discussed by employing cross condensation and H218O isotope labeling experiments. This method offers a straightforward access to α-acyloxycarboxamides bearing two identical functional groups in high yields under mild conditions.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(2S)-2-(Fluoromethyl)piperidine hydrochloride (1:1)
CAS Number:
886216-73-5
Molecular Formula:
C6H13ClFN
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