A new pathway towards polymer modified cellulose nanocrystals via a “grafting onto” process for drug delivery
Literature Information
Hairong Wang, Jinlin He, Mingzu Zhang, Kam Chiu Tam, Peihong Ni
Poly(ethyl ethylene phosphate) (PEEP) modified cellulose nanocrystals (CNCs) (CNC-g-PEEP) were synthesized through a “grafting onto” process, in which a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry was utilized. The resulting suspension of negatively-charged CNC-g-PEEP nanocrystals could be used to encapsulate doxorubicin (DOX) by electrostatic interactions and release the drug in the tumor cell environment.
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