A new pathway towards polymer modified cellulose nanocrystals via a “grafting onto” process for drug delivery

Literature Information

Publication Date 2015-04-17
DOI 10.1039/C5PY00466G
Impact Factor 5.582
Authors

Hairong Wang, Jinlin He, Mingzu Zhang, Kam Chiu Tam, Peihong Ni


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Abstract

Poly(ethyl ethylene phosphate) (PEEP) modified cellulose nanocrystals (CNCs) (CNC-g-PEEP) were synthesized through a “grafting onto” process, in which a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry was utilized. The resulting suspension of negatively-charged CNC-g-PEEP nanocrystals could be used to encapsulate doxorubicin (DOX) by electrostatic interactions and release the drug in the tumor cell environment.

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Polymer Chemistry

Polymer Chemistry
CiteScore: 8.6
Self-citation Rate: 7.3%
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Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

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