Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver cancer by folate-targeted quantum dot-based liposomes

Literature Information

Publication Date 2015-04-10
DOI 10.1039/C5BM00077G
Impact Factor 6.843
Authors

Dan Shao, Jing Li, Yue Pan, Xin Zhang, Xiao Zheng, Zheng Wang, Ming Zhang, Hong Zhang


View Original

Abstract

Theranostics is emerging as a popular strategy for cancer therapy; thanks to the development of nanotechnology. In this work, we have combined an HSV-TK/GCV suicide gene system and near-infrared quantum dots, as the former is quite effective in liver cancer treatment and the latter facilitates tumor imaging. A folate-modified theranostic liposome (FL/QD-TK) was developed, which is composed of an HSV-TK suicide gene covalently coupling with near-infrared fluorescent CdSeTe/ZnS core/shell quantum dots. The liver cancer-targeting and biosafety of FL/QD-TK were studied in vitro and in vivo. FL/QD-TK exhibited highly specific tumor imaging and strong inhibition of the folate receptor-overexpressed Bel-7402 mouse xenografts without systematic toxicity. This study may shed light on gene delivery and targeted cancer therapy.

Related Literature

Hydrogen oxidation at the Pt–BaZr0.1Ce0.7Y0.1Yb0.1O3−δ (BZCYYb) interface

Mingfei Liu, Shi Feng, Wei Liu, Hyeon Cheol Park, Meilin Liu

2013-01-21 Paper

DOI: 10.1039/C3CP44225J

Effect of multilayer structure on cyclic performance of Si/Fe anode electrode in Lithium-ion secondary batteries

Hee-Kook Kang, Seong-Rae Lee, Won Il Cho, Byung Won Cho

2012-11-22 Paper

DOI: 10.1039/C2CP42824E

Can hydrate form in carbon dioxide from dissolved water?

Bjørn Kvamme, Tatiana Kuznetsova, Pilvi-Helina Kivelæ, Jordan Bauman

2012-11-28 Paper

DOI: 10.1039/C2CP43061D

On the methods of calculation of the charge collection efficiency of dye sensitized solar cells

Luca Bertoluzzi, Shuai Ma

2013-02-04 Communication

DOI: 10.1039/C3CP44248A

Fabrication and photoelectrochemical properties of ZnS/Au/TiO2nanotube array films

Yan-Feng Zhu, Juan Zhang, Lu Xu, Ya Guo, Xiao-Ping Wang, Rong-Gui Du, Chang-Jian Lin

2013-01-22 Paper

DOI: 10.1039/C3CP43572E

The whole process of phase transition and relaxation of poly(N-isopropylacrylamide) aqueous solution

Hayato Inoue, Shota Kuwahara, Kenji Katayama

2013-01-21 Paper

DOI: 10.1039/C3CP43309A

Organic photovoltaic devices with colloidal TiO2nanorods as key functional components

Luisa De Marco, Maria R. Belviso, Gianvito Caputo

2012-02-10 Paper

DOI: 10.1039/C2CP23971J

Unraveling the binding interaction and kinetics of a prospective anti-HIV drug with a model transport protein: results and challenges

Bijan Kumar Paul, Debarati Ray, Nikhil Guchhait

2012-11-21 Paper

DOI: 10.1039/C2CP42539D

A new type of low-cost counter electrode catalyst based on platinum nanoparticles loaded onto silicon carbide (Pt/SiC) for dye-sensitized solar cells

Sining Yun, Liang Wang, Chunyu Zhao, Yanxiang Wang, Tingli Ma

2013-02-01 Communication

DOI: 10.1039/C3CP44048F

Molecular dynamics simulations of wild type and mutants of human complement receptor 2 complexed with C3d

Hua Wan, Jian-ping Hu, Xu-hong Tian, Shan Chang

2012-11-09 Paper

DOI: 10.1039/C2CP41388D

You might also like

Compound Q&A

What industries use 4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine (CAS: 1015845-73-4)?

4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine finds applications in various industri...

1015845-73-44-(4-tert-Butylpheny...
Compound Q&A

What industries use H3TATAB (CAS: 63557-10-8)?

H3TATAB is used in the pharmaceutical industry for the synthesis of certain orga...

63557-10-8H3TATAB
Compound Q&A

What are the main uses of 1-Ethyl-3-fluorobenzene (CAS: 696-39-9)?

1-Ethyl-3-fluorobenzene (CAS: 696-39-9) is primarily used as a precursor in the ...

696-39-91-Ethyl-3-fluorobenz...
Compound Q&A

What are the main uses of 1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid (CAS: 851484-94-1)?

1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid is prim...

851484-94-11-(tert-Butoxycarbon...
Compound Q&A

What are the physical and chemical properties of 1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0)?

1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0) is a colorless or white crystalli...

359880-05-01-Cyclobutyl-4-piper...
Compound Q&A

What is Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0)?

Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0) is a che...

575433-76-0Pyridine-2,6-dicarbo...
Compound Q&A

What is the market or research trend for 2,3-Difluorophenylalanine (CAS: 236754-62-4)?

The market for 2,3-Difluorophenylalanine (CAS: 236754-62-4) is growing with incr...

236754-62-42,3-Difluorophenylal...
Compound Q&A

How is (2-Hydroxy-1-naphthyl)boronic acid (CAS: 898257-48-2) typically synthesized?

(2-Hydroxy-1-naphthyl)boronic acid can be synthesized through the reduction of 2...

898257-48-2(2-Hydroxy-1-naphthy...
1315351-28-0tert-Butyl (5-bromo-...
Compound Q&A

Are there alternatives to 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-glucopyranoside (CAS: 19833-12-6) in synthesis?

While 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-gluc...

19833-12-65,7-Dihydroxy-4-oxo-...

Source Journal

Biomaterials Science

Biomaterials Science
CiteScore: 11.5
Self-citation Rate: 3.4%
Articles per Year: 492

Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions. Papers do not necessarily need to report a new biomaterial but should provide novel insight into the biological applications of the biomaterial. Articles that primarily focus on demonstrating novel materials chemistry and bring a molecular picture to bear on a given material’s suitability as a biomaterial are more suited to our companion journal, Journal of Materials Chemistry B. Biomaterials Science publishes primary research and review-type articles in the following areas: molecular design of biomaterials, including translation of emerging chemistries to biomaterials science of cells and materials at the nanoscale and microscale materials as model systems for stem cell and human biology materials for tissue engineering and regenerative medicine (Nano)materials and (nano)systems for therapeutic delivery interactions at the biointerface biologically inspired and biomimetic materials, including bio-inspired self-assembly systems and cell-inspired synthetic tools next-generation biomaterials tools and methods

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.