Cancer screening via infrared spectral cytopathology (SCP): results for the upper respiratory and digestive tracts

Literature Information

Publication Date 2015-09-28
DOI 10.1039/C5AN01751C
Impact Factor 4.616
Authors

Miloš Miljković, Benjamin Bird, Antonella I. Mazur, Jen M. Schubert, Douglas Townsend, Nora Laver, Max Almond, Oliver Old


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Abstract

Instrumental advances in infrared micro-spectroscopy have made possible the observation of individual human cells and even subcellular structures. The observed spectra represent a snapshot of the biochemical composition of a cell; this composition varies subtly but reproducibly with cellular effects such as progression through the cell cycle, cell maturation and differentiation, and disease. The aim of this summary is to provide a synopsis of the progress achieved in infrared spectral cytopathology (SCP) – the combination of infrared micro-spectroscopy and multivariate methods of analysis – for the detection of abnormalities in exfoliated human cells of the upper respiratory and digestive tract, namely the oral and nasopharyngeal cavities, and the esophagus.

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