Cancer screening via infrared spectral cytopathology (SCP): results for the upper respiratory and digestive tracts
Literature Information
Miloš Miljković, Benjamin Bird, Antonella I. Mazur, Jen M. Schubert, Douglas Townsend, Nora Laver, Max Almond, Oliver Old
Instrumental advances in infrared micro-spectroscopy have made possible the observation of individual human cells and even subcellular structures. The observed spectra represent a snapshot of the biochemical composition of a cell; this composition varies subtly but reproducibly with cellular effects such as progression through the cell cycle, cell maturation and differentiation, and disease. The aim of this summary is to provide a synopsis of the progress achieved in infrared spectral cytopathology (SCP) – the combination of infrared micro-spectroscopy and multivariate methods of analysis – for the detection of abnormalities in exfoliated human cells of the upper respiratory and digestive tract, namely the oral and nasopharyngeal cavities, and the esophagus.
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