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Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks
Literature Information
Publication Date
2015-11-20
DOI
10.1039/C5AN01743B
Impact Factor
4.616
Authors
C. Parmenter, D. J. Scurr, N. A. Russell
View Original
Abstract
Advanced data analysis tools are crucial for the application of ToF-SIMS analysis to biological samples. Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of neuronal cell cultures. The method readily provides access to sample component information and significantly improves the images’ signal-to-noise ratio (SNR).
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Analyst
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Self-citation Rate:
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
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