Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

Literature Information

Publication Date 2015-01-30
DOI 10.1039/C4PY01808G
Impact Factor 5.582
Authors

Suchithra A. Senevirathne, Suthida Boonsith, David Oupicky, Michael C. Biewer, Mihaela C. Stefan


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Abstract

The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment. Herein, we report the synthesis and characterization of valproic acid ester pro-drug micelles of amphiphilic polycaprolactone block copolymers and their potential applications in drug delivery.

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Polymer Chemistry

Polymer Chemistry
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