Synthesis and properties of CO2-switchable Dex-g-PAHMA copolymers

Literature Information

Publication Date 2014-09-02
DOI 10.1039/C4PY00987H
Impact Factor 5.582
Authors

Hongliang Kang, Ruigang Liu, Zhuang Li, Xiaozhong Qu


View Original

Abstract

Dextran graft poly((N-amidino)hexyl methacrylamide) (Dex-g-PAHMA) copolymers were synthesized by free radical polymerization in aqueous solution and characterized. Dex-g-PAHMA copolymers can self-assemble into micelles with the PAHMA rich core and dextran rich shell in aqueous media. The CO2 sensitivity of the micelles was investigated by dynamic light scattering (DLS), conductivity and zeta potential. The results confirmed that the Dex-g-PAHMA copolymer micelles have reversible CO2 sensitivity. The micelles can be used as doxorubicin (DOX) carriers and DOX molecules are mainly located in the core of the micelles. The MTT assay indicated that the Dex-g-PAHMA graft copolymers are non-toxic to cells in the copolymer concentration range of 5–1000 μg mL−1, whereas the relative cell viability is greatly reduced with the increase of copolymer concentration for DOX-loaded micelles. The DOX-loaded micelles can be endocytosed by MCF-7 cells and the DOX can release from micelles and diffuse into the cell nucleus. The Dex-g-PAHMA copolymers have promising applications as drug carriers for cancer therapy.

Related Literature

Contents list

2024-01-02 Front/Back Matter

DOI: 10.1039/D4VA90002B

Back cover

2024-01-03 Cover

DOI: 10.1039/D4SU90004A

Spent coffee ground–calcium alginate biosorbent for adsorptive removal of methylene blue from aqueous solutions

Herlys Viltres, Enelio Torres-García, Amin Reza Rajabzadeh, Seshasai Srinivasan, Ricardo A. Peralta, Ilich A. Ibarra, Carolina Leyva

2023-12-11 Paper

DOI: 10.1039/D3SU00365E

A simple approach to determining the efficacy of antiperspirants using paper-based colorimetric paper sensors: SweatSENSE

Rachel A. Hand, Spyridon Efstathiou, Alan M. Wemyss, Maria Grypioti, Gavin Kirby, Tammie Barlow, Emmett Cullen Tinley, Jane Ford, Andy Jamieson, Janette Reynolds, Jean Miller, Susan Bates, David M. Haddleton

2024-01-05 Paper

DOI: 10.1039/D3LP00214D

Contents list

2024-01-11 Front/Back Matter

DOI: 10.1039/D4EY90003K

Polypentenamer thermoplastic elastomers via copolymerization of cyclopentene and dicyclopentadiene

Daniel W. Weller, Robert Halbach, Alexander V. Zabula, Sarah J. Mattler, Xiaodan Gu, Carlos R. López-Barrón

2023-08-09 Paper

DOI: 10.1039/D3LP00076A

Operando insights into correlating CO coverage and Cu–Au alloying with the selectivity of Au NP-decorated Cu2O nanocubes during the electrocatalytic CO2 reduction

Clara Rettenmaier, Antonia Herzog, Daniele Casari, Martina Rüscher, Hyo Sang Jeon, David Kordus, Mauricio Lopez Luna, Stefanie Kühl, Uta Hejral, Earl M. Davis, See Wee Chee, Janis Timoshenko, Duncan T.L. Alexander, Arno Bergmann, Beatriz Roldan Cuenya

2023-10-25 Paper

DOI: 10.1039/D3EY00162H

Inside front cover

2023-11-17 Cover

DOI: 10.1039/D3LP90008H

Recent progress in the development of conductive hydrogels and the application in 3D printed wearable sensors

Yuxuan Lin, Ruxue Yang, Xin Wu

2023-08-22 Review Article

DOI: 10.1039/D3LP00077J

Chitosan/PVA-supported silver nanoparticles for azo dyes removal: fabrication, characterization, and assessment of antioxidant activity

Ismet Meydan, Aysenur Aygun, Rima Nour Elhouda Tiri, Tugba Gur, Yılmaz Kocak, Hamdullah Seckin, Fatih Sen

2023-11-22 Paper

DOI: 10.1039/D3VA00224A

You might also like

Compound Q&A

How should waste containing (6-Bromo-2-naphthyl)oxy](dimethyl)(2-methyl-2-propanyl)silane be handled?

Waste containing (6-Bromo-2-naphthyl)oxy](dimethyl)(2-methyl-2-propanyl)silane (...

100751-65-3[(6-Bromo-2-naphthyl...
Compound Q&A

How is 7-Fluoro-4-isoquinolinecarboxylic acid (CAS: 1841081-40-0) typically synthesized?

7-Fluoro-4-isoquinolinecarboxylic acid can be synthesized via a multi-step proce...

1841081-40-07-Fluoro-4-isoquinol...
Compound Q&A

What are the physical and chemical properties of 2,3,5,6-Tetrabromothieno[3,2-b]thiophene (CAS: 124638-53-5)?

2,3,5,6-Tetrabromothieno[3,2-b]thiophene is a crystalline compound with a high m...

124638-53-52,3,5,6-Tetrabromoth...
Compound Q&A

Is 1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (CAS: 1542705-92-9) safe?

1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indol...

1542705-92-91-[4-(Benzylamino)-7...
Compound Q&A

What is the market or research trend for imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3-methyl-4-oxo- (CAS: 113942-30-6)?

The market for imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3...

113942-30-6Imidazo[5,1-d]-1,2,3...
Compound Q&A

What is 3-(Triisopropylsilyl)propiolaldehyde (CAS: 163271-80-5)?

3-(Triisopropylsilyl)propiolaldehyde is a synthetic organic compound with the CA...

163271-80-53-(Triisopropylsilyl...
Compound Q&A

What regulatory guidelines apply to 6-Nitro-2H-1,4-benzoxazin-3(4H)-one (CAS: 81721-87-1)?

6-Nitro-2H-1,4-benzoxazin-3(4H)-one (CAS: 81721-87-1) is subject to various regu...

81721-87-16-Nitro-2H-1,4-benzo...
Compound Q&A

How should waste containing (3-Fluorophenyl)(4-{[(2-methyl-2-propanyl)oxy]carbonyl}-1-piperazinyl)acetic acid (CAS: 885272-91-3) be handled?

Waste containing (3-Fluorophenyl)(4-{[(2-methyl-2-propanyl)oxy]carbonyl}-1-piper...

885272-91-3(3-Fluorophenyl)(4-{...
Compound Q&A

What are the physical and chemical properties of N,N'-4,4'-Biphenyldiyldiisonicotinamide (CAS: 55119-40-9)?

N,N'-4,4'-Biphenyldiyldiisonicotinamide is a white crystalline solid with a mole...

55119-40-9N,N'-4,4'-Biphenyldi...
Compound Q&A

What industries use 6-Bromo-8-fluoro-2-quinazolinol (CAS: 1036756-15-6)?

6-Bromo-8-fluoro-2-quinazolinol is primarily used in the pharmaceutical industry...

1036756-15-66-Bromo-8-fluoro-2-q...

Source Journal

Polymer Chemistry

Polymer Chemistry
CiteScore: 8.6
Self-citation Rate: 7.3%
Articles per Year: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.