Semibranched polyglycidols as “fillers” in polycarbonate hydrogels to tune hydrophobic drug release
Literature Information
David M. Stevens, Anand Rahalkar, Benjamin Spears, Kelly Gilmore, Emily Douglas, Murugappan Muthukumar, Eva Harth
We report on the synthesis of polycarbonate based hydrogels that contain semibranched polyglycidols entrapped into the polycarbonate-diethylene oxide matrix. The primary OH groups of the polyglycidol can also react in a transesterification reaction to form reconfigurable crosslinked materials. We first synthesized allyl and ethylene-oxide functionalized linear polycarbonates with Sn(OTf)2 as catalyst and isoamyl alcohol as initiator. In a reaction with dithiol ethylene oxide and dithiol (poly ethylene oxide) 1.5k, a crosslinked network was formed via thiolene click reactions in the presence or absence of semibranched polyglycidols. The resulting four hydrogels were analyzed for their swelling capabilities, mechanical properties and degradation in phosphate buffered saline. Paclitaxel was chosen as a model drug to study the drug release from these two carriers and was incorporated during the crosslinking reaction. The presence of the polyglycidol as well as the length of the dithiol crosslinker influenced the swelling capabilities, were responsible for a varied drug release behavior and the remarkable stress resistance. The present work introduces and compares polyglycidols as components in polycarbonate crosslinked materials that are either entrapped or covalently attached to the polycarbonate backbone to establish models of structure property relationships for hydrogels used for controlled drug delivery in vivo.
Related Literature
Catalytic mechanism of the PrhA (V150L/A232S) double mutant involved in the fungal meroterpenoid biosynthetic pathway: a QM/MM study
Jie Bai, Lijuan Yan, Yongjun Liu
DOI: 10.1039/C9CP03565F
Tuning the structure, thermal stability and rheological properties of liquid crystal phases via the addition of silica nanoparticles
Joshua B. Marlow, Thomas M. McCoy, Cat Q. Ho, Liliana de Campo, Robert Knott, Toby D. M. Bell, Rico F. Tabor
DOI: 10.1039/C9CP04908H
Accurate predictions of aqueous solubility of drug molecules via the multilevel graph convolutional network (MGCN) and SchNet architectures
Peng Gao, Yuzhu Sun, Jianguo Yu
DOI: 10.1039/D0CP03596C
Matrix infrared spectroscopy of F2BMF and FBWF2 (M = Cr, Mo and W) complexes and quantum chemistry calculations
Bing Xu, Wenjing Li, Zhen Pu, Wenjie Yu, Tengfei Huang, Juanjuan Cheng, Xuefeng Wang
DOI: 10.1039/C9CP04888J
The reaction of O(3P) with alkynes: a dynamic and computational study focusing on formyl radical production
Andrew D. Buettner, Benjamin J. Dilday, Rachel A. Craigmile, Matthew C. Drummer, Jean M. Standard, Robert W. Quandt
DOI: 10.1039/D0CP03698F
Single-molecule kinetic studies of DNA hybridization under extreme pressures
DOI: 10.1039/D0CP04035E
Can modified DNA base pairs with chalcogen bonding expand the genetic alphabet? A combined quantum chemical and molecular dynamics simulation study
Preetleen Kathuria, Stacey D. Wetmore, Purshotam Sharma
DOI: 10.1039/D0CP04921B
Bulk and grain boundary Li-diffusion in dense LiMn2O4 pellets by means of isotope exchange and ToF-SIMS analysis
C. Schwab, A. Höweling, A. Windmüller, J. Gonzalez-Julian, S. Möller, J. R. Binder, S. Uhlenbruck, O. Guillon
DOI: 10.1039/C9CP05128G
Theoretical investigation of protonated thiophene and two of its nitrile substituted derivatives (2-cyanothiophene and 3-cyanothiophene)
Minh Tho Nguyen
DOI: 10.1039/D0CP03154B
You might also like
What are the main uses of (5-Sulfamoyl-3-pyridinyl)boronic acid (CAS: 951233-61-7)?
(5-Sulfamoyl-3-pyridinyl)boronic acid is primarily used in chemical synthesis, p...
How is Benzyl 2-methyl-2-(methylsulfonyl)-4-pentenoate (CAS: 1942858-50-5) typically synthesized?
Benzyl 2-methyl-2-(methylsulfonyl)-4-pentenoate is typically synthesized via est...
What precautions should be taken when handling 8-Fluoroquinolin-6-ol (CAS: 209353-22-0)?
When handling 8-Fluoroquinolin-6-ol (CAS: 209353-22-0), it is important to use p...
What are the physical and chemical properties of 1,3-Dibromo-5-(2-methyl-2-propanyl)benzene (CAS: 129316-09-2)?
1,3-Dibromo-5-(2-methyl-2-propanyl)benzene (CAS: 129316-09-2) is a crystalline c...
What industries use Ethyl 7-chloro-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate (CAS: 174726-87-5)?
Ethyl 7-chloro-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carbox...
What precautions should be taken when handling Delta-7-Avenasterol (CAS: 23290-26-8)?
When handling Delta-7-Avenasterol (CAS: 23290-26-8), it is important to wear app...
What precautions should be taken when handling N-({(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide (CAS: 872992-20-6)?
Proper handling involves the use of personal protective equipment such as gloves...
What precautions should be taken when handling 2-Methyl-2-proanyl 4-[(2-aminophenyl)amino]-1-piperidinecarboxylate (CAS: 79099-00-6)?
When handling 2-Methyl-2-proanyl 4-[(2-aminophenyl)amino]-1-piperidinecarboxylat...
What is N-Methyl-4-chlorobenzylamine hydrochloride (CAS: 65542-24-7)?
N-Methyl-4-chlorobenzylamine hydrochloride (CAS: 65542-24-7) is a organic compou...
Is [2-(Dodecyloxy)ethoxy]acetic acid (CAS: 27306-90-7) safe?
[2-(Dodecyloxy)ethoxy]acetic acid (CAS: 27306-90-7) is generally considered safe...
Source Journal
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.











![5-Chloropyrrolo[2,1-f][1,2,4]triazin-4(3H)-one structure 5-Chloropyrrolo[2,1-f][1,2,4]triazin-4(3H)-one structure](https://static.chemtradehub.com/structs/888/888720-60-3-4f7c.webp)


![4-Fluoro-2-(4-{[(3S,4R)-4-(2-hydroxy-2-propanyl)-3-pyrrolidinyl]amino}-6,7-dimethoxy-2-quinazolinyl)phenol hydrochloride (1:1) structure 4-Fluoro-2-(4-{[(3S,4R)-4-(2-hydroxy-2-propanyl)-3-pyrrolidinyl]amino}-6,7-dimethoxy-2-quinazolinyl)phenol hydrochloride (1:1) structure](https://static.chemtradehub.com/structs/143/1431697-96-9-619c.webp)