Reactive imidazole intermediates: simplified synthetic approach to functional aliphatic cyclic carbonates
Literature Information
Johan V. Olsson, Daniel Hult, Yanling Cai, Sandra García-Gallego, Michael Malkoch
Reactive imidazole intermediates based on AB2 and A3 monomers, i.e. bis(methylol) propionic acid (bis-MPA) and trimethylolpropane (TMP) have successfully been synthesized and isolated on a 100 gram scale via a facile synthetic protocol using 1,1′-carbonyldiimidazole (CDI) as a key reagent. The robustness of the imidazole intermediates as bench stable precursors enabled the synthesis of a library of functional cyclic carbonates bearing relevant functionalities including hydrophilic PEGs, bioactive cholesterol and clickable groups. A number of functional polycarbonates were obtained by ring-opening polymerization, and their relevance in biomedical applications was highlighted by their low cytotoxicity on human dermal fibroblasts (hDF).
Related Literature
Surface features and catalytic activity of sulfated zirconia catalysts from hydrothermal precursors
C. Morterra, G. Cerrato, S. Ardizzone, C. L. Bianchi, M. Signoretto, F. Pinna
DOI: 10.1039/B110444F
EPR spectrum and formation properties of a cubic Rh+ centre in NaCl
H. Vrielinck, F. Callens, P. Matthys
DOI: 10.1039/B110906P
Theoretical analysis of the oxocarbons: The role played by the solvent and counter-ions in the electronic spectrum of the deltate ion
Willian R. Rocha, Wagner B. De Almeida, Hélio F. Dos Santos
DOI: 10.1039/B109738E
Very high resolution near-field chemical imaging using an infrared free electron laser
G. Margaritondo, D. Talley, J. S. Sanghera, I. D. Aggarwal, N. H. Tolk
DOI: 10.1039/B109279K
Active sites on an oxidecatalyst for F/Cl-exchange reactions: X-ray spectroscopy of fluorinated γ-Al2O3
Wolfgang E. S. Unger, Erhard Kemnitz, Sven L. M. Schroeder
DOI: 10.1039/B110792E
Site selective hydroxylation of the MgO surface
O. Diwald, M. Sterrer, E. Knözinger
DOI: 10.1039/B110334B
Scanning plasmon near-field microscopy: signal–noise ratio of different registration schemes and prospects for single molecule detection
V. N. Konopsky, S. A. Saunin, V. A. Bykov, E. A. Vinogradov
DOI: 10.1039/B109955H
Ablation of noble metals in liquids: a method to obtain nanoparticles in a thin polymeric film
Giuseppe Compagnini, Alessandro A. Scalisi, Orazio Puglisi
DOI: 10.1039/B109490D
Potential energy and free energy surfaces of the formic acid dimer: Correlated ab initio calculations and molecular dynamics simulations
Jana Chocholoušová, Jaroslav Vacek, Pavel Hobza
DOI: 10.1039/B110872G
You might also like
How should waste containing (6-Bromo-2-naphthyl)oxy](dimethyl)(2-methyl-2-propanyl)silane be handled?
Waste containing (6-Bromo-2-naphthyl)oxy](dimethyl)(2-methyl-2-propanyl)silane (...
How is 7-Fluoro-4-isoquinolinecarboxylic acid (CAS: 1841081-40-0) typically synthesized?
7-Fluoro-4-isoquinolinecarboxylic acid can be synthesized via a multi-step proce...
What are the physical and chemical properties of 2,3,5,6-Tetrabromothieno[3,2-b]thiophene (CAS: 124638-53-5)?
2,3,5,6-Tetrabromothieno[3,2-b]thiophene is a crystalline compound with a high m...
Is 1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (CAS: 1542705-92-9) safe?
1-[4-(Benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indol...
What is the market or research trend for imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3-methyl-4-oxo- (CAS: 113942-30-6)?
The market for imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid, 3,4-dihydro-3...
What is 3-(Triisopropylsilyl)propiolaldehyde (CAS: 163271-80-5)?
3-(Triisopropylsilyl)propiolaldehyde is a synthetic organic compound with the CA...
What regulatory guidelines apply to 6-Nitro-2H-1,4-benzoxazin-3(4H)-one (CAS: 81721-87-1)?
6-Nitro-2H-1,4-benzoxazin-3(4H)-one (CAS: 81721-87-1) is subject to various regu...
How should waste containing (3-Fluorophenyl)(4-{[(2-methyl-2-propanyl)oxy]carbonyl}-1-piperazinyl)acetic acid (CAS: 885272-91-3) be handled?
Waste containing (3-Fluorophenyl)(4-{[(2-methyl-2-propanyl)oxy]carbonyl}-1-piper...
What are the physical and chemical properties of N,N'-4,4'-Biphenyldiyldiisonicotinamide (CAS: 55119-40-9)?
N,N'-4,4'-Biphenyldiyldiisonicotinamide is a white crystalline solid with a mole...
What industries use 6-Bromo-8-fluoro-2-quinazolinol (CAS: 1036756-15-6)?
6-Bromo-8-fluoro-2-quinazolinol is primarily used in the pharmaceutical industry...
Source Journal
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.














