Ultra bright red AIE dots for cytoplasm and nuclear imaging
Literature Information
Zilong Wang, Lulin Yan, Lei Zhang, Yujue Chen, Hui Li, Jibo Zhang, Yan Zhang, Xing Li, Bin Xu, Xueqi Fu, Zaicheng Sun, Wenjing Tian
An aggregation-induced emission (AIE) molecule (2-(2,6-bis((E)-2-(5-(N,N-bis(4-((E)-2-(10-((E)-4-(diphenylamino)styryl)anthracen-9-yl)vinyl)phenyl)aniline-4-yl)thiophen-2-yl)vinyl)-4H-pyran-4-ylidene)malononitrile) (TPA-AN-TPM) with near-infrared emission was synthesized by coating a disc-like red emission fluorophore with a propeller-shaped AIE fluorophore. The ultrabright red AIE dots TPA-AN-TPM@PS-PVP (TPA-AN-TPM in poly(styrene)-poly(4-vinylpyridine) nanoparticles) with an absolute quantum yield of 12.9% were fabricated by using the AIE molecule TPA-AN-TPM as the core and one biocompatible polymer PS-PVP as the encapsulation matrix. The AIE dots are mono-dispersed with an average diameter of 25 nm, and are stable in an aqueous suspension. In particular, the AIE dots can stain both the cytoplasm and the nuclei with a strong red fluorescence signal, and pose little toxicity to living cells.
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