Synthesis and biomedical applications of functional poly(α-hydroxyl acid)s
Literature Information
Publication Date
2014-07-10
DOI
10.1039/C4PY00667D
Impact Factor
5.582
Authors
Yun Yu, Jiong Zou, Chong Cheng
View Original
Abstract
Poly(α-hydroxyl acid)s (PAHAs) are an important class of biocompatible and biodegradable polymers. However, biomedical applications of conventional PAHAs have been restricted by the lack of functional groups. Therefore, recently there have been significant research activities to design and synthesize functional PAHAs, and subsequently investigate their applications in biomedical areas. In this review, we present an overview on synthesis and biomedical applications of functional PAHAs. The synthetic approaches to incorporate functionalities with PAHAs as pendent groups are addressed. Applications of these functional PAHAs in drug delivery, gene delivery, co-delivery of drugs and genes, and functionalization with biomolecules are highlighted.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
![4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate structure](https://static.chemtradehub.com/structs/740/740081-22-5-f58f.webp "4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate structure")
4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate
CAS Number:
740081-22-5
Molecular Formula:
C17H13ClFN3O3
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