In vitro and in vivo application of hydroxypropyl-β-cyclodextrin-grafted polyethyleneimine used as a transdermal penetration enhancer

Literature Information

Publication Date 2014-03-14
DOI 10.1039/C4PY00286E
Impact Factor 5.582
Authors

Ke Wang, Yan Yan, Guilan Zhao, Wei Xu, Kai Dong, Cuiyu You, Lu Zhang, Jianfeng Xing


View Original

Abstract

Biodegradable cationic polymers have a promising application in transdermal drug delivery. In this study, hydroxypropyl-β-cyclodextrin-grafted polyethyleneimine (HP-β-CD–PEI) were prepared, and these polymers were developed as a penetration enhancer. The aim of this study was to evaluate the in vitro and in vivo application of the transdermal permeation enhancement of HP-β-CD–PEI with different molecular weights (Mol. Wt) of polyethyleneimine (PEI). HP-β-CD–PEI with different Mol. Wt of PEI (600, 1.8 kDa and 10 kDa) were synthesized and characterized by 1H NMR. The effect of HP-β-CD–PEI on the stratum corneum was studied by attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR). In vitro prostaglandin E2 (PGE2) release by cell culture, and skin morphological changes were determined to examine the irritation of the skin by HP-β-CD–PEI. Vitamin B12 was chosen as a model drug to examine the enhancing capacity of this enhancer. Both in vitro permeation by Franz cells and in vivo kinetics of skin disposition were performed to determine the drug permeation by HP-β-CD–PEI. The drug with the enhancer was penetrated through mice skin for 3, 6, and 9 h, and the cumulative drug content deposited in the epidermis and dermis was measured. The results showed that the HP-β-CD–PEI could be a promising enhancer for topical drug delivery.

Related Literature

Contents list

2023-12-19 Front/Back Matter

DOI: 10.1039/D4SE90002B

Solvent-controlled synthesis of hydrophilic and hydrophobic carbon dots

Chenhan Zhang, Zhihua Ying, Yuan Jiang, Haiyang Wang, Xuebin Zhou, Weipeng Xuan, Peng Zheng

2023-12-08 Paper

DOI: 10.1039/D3CP04273A

Correlated proton dynamics in hydrogen bonding networks: the benchmark case of 3-hydroxyglutaric acid

Bruno Martínez-Haya, Juan Ramón Avilés-Moreno, Francisco Gámez, Jonathan Martens, Jos Oomens, Giel Berden

2023-11-28 Paper

DOI: 10.1039/D3CP04514E

In situ construction of heterostructured CuxO@NiCoS nanoarrays for alkaline overall water splitting

Chenyu Song, Jishuang Yang, Chinnadurai Ayappan, Haitang Yang, Ruimin Xing, Shanhu Liu

2023-12-02 Paper

DOI: 10.1039/D3SE01194A

Exploring the structural stability and electrochemical performance of B doped T-graphene nanotubes from first-principles calculations

Ruyan Zhang, Yuhua Hou, Xialei Guo, Xinyu Li, Wei Li, Xiaoma Tao, Youlin Huang

2023-11-29 Paper

DOI: 10.1039/D3CP04143C

Contents list

2023-11-21 Front/Back Matter

DOI: 10.1039/D3SE90089D

Group 13 five- and six-membered rings with rare 2π aromaticity

Yutong Huo, Xiaojiao Gu, Xinde Li, Peng Jin

2023-11-24 Paper

DOI: 10.1039/D3CP04159J

You might also like

Compound Q&A

What is Ethyl 3-cyclohexylpropanoate (CAS: 10094-36-7)?

Ethyl 3-cyclohexylpropanoate is a clear, colorless to light yellow liquid with a...

10094-36-7Ethyl 3-cyclohexylpr...
Compound Q&A

How should waste containing 2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl)nicotinic acid (CAS: 34783-31-8) be handled?

Waste containing 2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl...

34783-31-82-(Hydroxymethyl)-5-...
Compound Q&A

How should waste containing 2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine (CAS: 858-46-8) be handled?

Waste containing 2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine (CAS: 858-46-8) sho...

858-46-82,4,6-Tris(pentafluo...
Compound Q&A

What precautions should be taken when handling Chloroac-nle-oh (CAS: 56787-36-1)?

When handling Chloroac-nle-oh (CAS: 56787-36-1), it is essential to wear appropr...

56787-36-1Chloroac-nle-oh
Compound Q&A

What industries use Ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 752244-05-6)?

Ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-3-carboxylate is primarily used in the...

752244-05-6Ethyl 6-phenylimidaz...
Compound Q&A

Are there alternatives to alpha-(2-Bromophenyl)benzylamine (CAS: 55095-15-3) in synthesis?

Alternatives to alpha-(2-Bromophenyl)benzylamine (CAS: 55095-15-3) in synthesis ...

55095-15-3alpha-(2-Bromophenyl...
Compound Q&A

How should waste containing 2-Chloro-5-methoxypyridine (CAS: 139585-48-1) be handled?

Waste containing 2-Chloro-5-methoxypyridine (CAS: 139585-48-1) should be managed...

139585-48-12-Chloro-5-methoxypy...
Compound Q&A

What industries use 1-(4-Methoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS: 5044-27-9)?

1-(4-Methoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS: 5044-27-9) is used in various ...

5044-27-91-(4-Methoxyphenyl)-...
Compound Q&A

Are there alternatives to 3-Bromo-5-(N-Boc)aminomethylisoxazole (CAS: 903131-45-3) in synthesis?

There are alternative reagents and compounds that can be used in the synthesis o...

903131-45-33-Bromo-5-(N-Boc)ami...
Compound Q&A

What is Tungsten(IV) oxide (CAS: 12036-22-5)?

Tungsten(IV) oxide, also known as tungsten dioxide, is a chemical compound with ...

12036-22-5Tungsten(IV) oxide

Source Journal

Polymer Chemistry

Polymer Chemistry
CiteScore: 8.6
Self-citation Rate: 7.3%
Articles per Year: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.