Reaction mediated artificial cell termination: control of vesicle viability using Rh(i)-catalyzed hydrogenation
Literature Information
Hirokazu Komatsu, Yuki Daimon, Kohsaku Kawakami, Motomu Kanai
Methods for artificial cell control by applying catalytic processes are receiving increasing attention as a basis for artificial control of cellular functions. Here we have developed a Rh(I)-based catalytic hydrogenation reaction of unsaturated bonds of lipids that make up vesicles contained in aqueous media. The reduction reaction was applied to vesicles revealing that oleate vesicles collapse following catalytic reduction with H2 and a Rh(I) catalyst, while the distribution of EggPC liposomes was increased following the reaction. Proliferation and size of the vesicles could thus be controlled by catalysis based on variations in fluidity of the vesicle membrane. This process is applicable for use in artificial cells and/or even living cellular systems.
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Source Journal
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.












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