![2-Hydroxy-4-[({[(4-methylphenyl)sulfonyl]oxy}acetyl)amino]benzoic acid structure](https://static.chemtradehub.com/structs/501/501919-59-1-579f.webp "2-Hydroxy-4-[({[(4-methylphenyl)sulfonyl]oxy}acetyl)amino]benzoic acid structure")
2-Hydroxy-4-[({[(4-methylphenyl)sulfonyl]oxy}acetyl)amino]benzoic acid
CAS Number:
501919-59-1
Molecular Formula:
C16H15NO7S
A WS2 nanosheet-based platform for fluorescent DNA detection via PNA–DNA hybridization
Literature Information
Publication Date
2014-11-07
DOI
10.1039/C4AN01738B
Impact Factor
4.616
Authors
Shuting Wang, Yulin Zhang, Yong Ning, Guo-Jun Zhang
View Original
Abstract
The WS2 nanosheet, a two-dimensional layered nanomaterial, shows high fluorescence quenching ability for the dye-labeled ssDNA. Currently, most of the fluorescent DNA detection methods employ DNA as a probe for recognition of target DNA. Peptide nucleic acid (PNA) is a DNA mimic but a neutral molecule, showing superior hybridization properties to target DNA. Based on the unique properties of WS2 nanosheet and PNA–DNA hybridization, we have developed a rapid, simple, stable and sensitive approach for DNA detection based on good fluorescence quenching ability of the WS2 nanosheet as well as high binding affinity and specificity of PNA to DNA. This novel assay is capable of exhibiting high sensitivity and specificity with a detection limit of 500 pM, and discriminating between single bases.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
(3beta,22E)-Stigmasta-5,22-dien-3-yl beta-D-glucopyranoside
CAS Number:
19716-26-8
Molecular Formula:
C35H58O6
![(1R)-3-Bromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one structure](https://static.chemtradehub.com/structs/102/10293-06-8-dd8a.webp "(1R)-3-Bromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one structure")
(1R)-3-Bromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
CAS Number:
10293-06-8
Molecular Formula:
C10H15BrO
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