Conversion of a laboratory-based test for phenylalanine detection to a simple paper-based format and implications for PKU screening in low-resource settings
Literature Information
Publication Date
2014-11-26
DOI
10.1039/C4AN01627K
Impact Factor
4.616
Authors
Gregory Thiessen, Robert Robinson, Kim De Los Reyes, Raymond J. Monnat, Jr.
View Original
Abstract
Laboratory-based testing does not reach many individuals in lower-resource settings who could benefit from access to appropriate tests for diagnosis and therapy. A critical issue is laboratory-based testing often requires an environment with a high level of resources and supporting infrastructure that is not available in many areas of the world. The current report describes the conversion of a laboratory-based test for phenylalanine detection to a simple paper-based test appropriate for use in low-resource settings. The paper-based test is easy to operate, with all reagents stored dry on the card, is compatible with visible detection for clinically relevant concentrations of phenylalanine, and has a time to result of 10 minutes. Next steps for test development are discussed in the context of the potential for the paper-based Phe test to be used as a newborn PKU screening test in settings that are not well served by existing screening approaches.
Related Literature
Viable aromatic BenHn stars enclosing a planar hypercoordinate boron or late transition metal
Xue-Feng Zhao, Jia-Jia Li, Hai-Ru Li, Caixia Yuan, Xinxin Tian, Si-Dian Li, Yan-Bo Wu, Zhi-Xiang Wang
2018-02-19
Paper
DOI: 10.1039/C7CP06955C
Substituent control of the ultrafast twisted intramolecular charge transfer rate in dimethylaminochalcone derivatives
2018-02-06
Paper
DOI: 10.1039/C7CP08239H
Ammonolysis of ketene as a potential source of acetamide in the troposphere: a quantum chemical investigation
Saptarshi Sarkar, Subhasish Mallick, Pradeep Kumar, Biman Bandyopadhyay
2018-04-25
Paper
DOI: 10.1039/C8CP01650J
Chemistry through cocrystals: pressure-induced polymerization of C2H2·C6H6 to an extended crystalline hydrocarbon
Matthew D. Ward, Haw-Tyng Huang, Li Zhu, Arani Biswas, Dmitry Popov, Timothy A. Strobel
2018-02-02
Paper
DOI: 10.1039/C7CP07852H
Pressure-induced emission band separation of the hybridized local and charge transfer excited state in a TPE-based crystal
Xuedan Liu, Aisen Li, Weiqing Xu, Zhiyong Ma, Xinru Jia
2018-04-28
Paper
DOI: 10.1039/C8CP02096E
Solvation-controlled lithium-ion complexes in a nonflammable solvent containing ethylene carbonate: structural and electrochemical aspects
Michiru Sogawa, Hikaru Kawanoue, Yanko Marinov Todorov, Daisuke Hirayama, Hideyuki Mimura, Nobuko Yoshimoto, Masayuki Morita, Kenta Fujii
2018-02-09
Paper
DOI: 10.1039/C7CP08511G
Isomer-specific detection in the UV photodissociation of the propargyl radical by chirped-pulse mm-wave spectroscopy in a pulsed quasi-uniform flow
Bernadette M. Broderick, Nicolas Suas-David, Nureshan Dias, Arthur G. Suits
2017-11-13
Paper
DOI: 10.1039/C7CP06211G
The structure–electrochemical property relationship of quinone electrodes for lithium-ion batteries
Licheng Miao, Luojia Liu, Zhenfeng Shang, Yixin Li, Yong Lu, Fangyi Cheng, Jun Chen
2018-04-17
Paper
DOI: 10.1039/C8CP00597D
Phase equilibrium and physical properties of biobased ionic liquid mixtures
Ariel A. C. Toledo Hijo, Guilherme J. Maximo, Rosiane L. Cunha, Felipe H. S. Fonseca, Lisandro P. Cardoso, Jorge F. B. Pereira, Mariana C. Costa, Eduardo A. C. Batista, Antonio J. A. Meirelles
2018-02-01
Paper
DOI: 10.1039/C7CP06841G
Imperfect mixing as a dominant factor leading to stochastic behavior: a new system exhibiting crazy clock behavior
László Valkai, Attila K. Horváth
2018-05-11
Paper
DOI: 10.1039/C8CP01156G
You might also like
Compound Q&A
What precautions should be taken when handling 2-Chloro-1,2-bis(4-methylphenyl)ethanone (CAS: 71193-32-3)?
When handling 2-Chloro-1,2-bis(4-methylphenyl)ethanone (CAS: 71193-32-3), it is ...
71193-32-32-Chloro-1,2-bis(4-m...
Compound Q&A
What industries use 4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)benzenesulfonyl chloride (CAS: 224789-26-8)?
4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl...
224789-26-84-Ethoxy-3-(5-methyl...
Compound Q&A
How should Methyl 3-Oxo-4-Androsten-17-Carboxylate (CAS: 2681-55-2) be stored?
Methyl 3-Oxo-4-Androsten-17-Carboxylate (CAS: 2681-55-2) should be stored in a c...
2681-55-2Methyl 3-Oxo-4-Andro...
Compound Q&A
What are the main uses of (R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid (CAS: 909725-61-7)?
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid is primarily used i...
909725-61-7(R)-3-Amino-4-(3-hex...
Compound Q&A
What regulatory guidelines apply to 2-Methyl-2-propanyl 3-amino-3-carbamoyl-1-azetidinecarboxylate (CAS: 1254120-14-3)?
2-Methyl-2-propanyl 3-amino-3-carbamoyl-1-azetidinecarboxylate (CAS: 1254120-14-...
1254120-14-32-Methyl-2-propanyl ...
Compound Q&A
Are there alternatives to (E)-4-(tert-Butoxy)-4-oxobut-2-enoic acid (CAS: 135355-96-3) in synthesis?
There are alternative reagents that can be used in synthesis instead of (E)-4-(t...
135355-96-3(E)-4-(tert-Butoxy)-...
Compound Q&A
What are the physical and chemical properties of [2-(3-Chlorophenyl)-1,3-thiazol-4-yl]methanol (CAS: 121202-20-8)?
[2-(3-Chlorophenyl)-1,3-thiazol-4-yl]methanol (CAS: 121202-20-8) is a crystallin...
121202-20-8[2-(3-Chlorophenyl)-...
Compound Q&A
What is the market or research trend for Methyl (2S)-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]{[(4-methylphenyl)sulfonyl]oxy}acetate (CAS: 166249-17-8)?
The market and research trends for Methyl (2S)-[(4S)-2,2-dimethyl-1,3-dioxolan-4...
166249-17-8Methyl (2S)-[(4S)-2,...
Compound Q&A
What is the market or research trend for 1-Bromo-2-isocyanatoethane (CAS: 42865-19-0)?
The market for 1-Bromo-2-isocyanatoethane (CAS: 42865-19-0) is driven by its use...
42865-19-01-Bromo-2-isocyanato...
Compound Q&A
What are the main uses of 4-Nitro-D-phenylalanine hydrochloride (CAS: 147065-06-3)?
4-Nitro-D-phenylalanine hydrochloride (CAS: 147065-06-3) is primarily used in re...
147065-06-34-Nitro-D-phenylalan...
Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
N-Methyl-2-(4-nitrophenyl)ethanamine hydrochloride (1:1)
CAS Number:
166943-39-1
Molecular Formula:
C9H13ClN2O2
(3beta,22E)-Stigmasta-5,22-dien-3-yl beta-D-glucopyranoside
CAS Number:
19716-26-8
Molecular Formula:
C35H58O6
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.