Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

Literature Information

Publication Date 2013-07-16
DOI 10.1039/C3PY00849E
Impact Factor 5.582
Authors

Haijun Yu, Zhiai Xu, Dangge Wang, Xianzhi Chen, Zhiwen Zhang, Qi Yin, Yaping Li


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Abstract

Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a “silent” state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.

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