The production of propionic acid, propanol and propylene via sugar fermentation: an industrial perspective on the progress, technical challenges and future outlook
Literature Information
Brandon A. Rodriguez, Chris C. Stowers, Viet Pham, Brad M. Cox
Propionic acid, n-propanol and propylene are chemicals in a variety of markets ranging from plastics to food preservatives. Propylene is an important commodity monomer and precursor to many chemical products, while propionic acid and n-propanol are smaller volume chemicals with growth potential. In place of petrochemicals, carbohydrates are a possible feedstock to all three by fermentative production of propionic acid followed by synthetic derivation of n-propanol and propylene through chemical reductions. There are few studies that directly assess the industrial practicality of this process despite five decades of scientific literature describing propionic acid fermentation with Propionibacterium. The work herein describes a sugar fermentation process evaluation for propionic acid production that achieved productivities at commercial levels, reaching yields of 0.55 g g−1 and reducing media costs to less than $1.00 per kg. Industrial scalability was explored via modeling fermentor size, raw material costs and capital, in order to compete with a conventional petrochemical route. Extra attention was given to separations, as aqueous acid separation is energy intensive and has frequently rendered biological processes non-competitive. Economic analysis and conceptual process evaluation of each of these experimentally supported steps combined resulted in targets to produce a cost competitive route to biologically derived propionic acid and subsequent n-propanol and propylene derivatives. Product yield from sugar was shown to be a key component of any successful propionic acid with a 0.6 g g−1 yield being immediately competitive. These findings prescribe and prioritize remaining parameters for subsequent research seeking to develop a cost-competitive bio-chemical route to C3 materials.
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Green Chemistry provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on, but not limited to, the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998). Green chemistry is the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry is at the frontiers of this continuously-evolving interdisciplinary science and publishes research that attempts to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. Submissions on all aspects of research relating to the endeavour are welcome. The journal publishes original and significant cutting-edge research that is likely to be of wide general appeal. To be published, work must present a significant advance in green chemistry. Papers must contain a comparison with existing methods and demonstrate advantages over those methods before publication can be considered. For more information please see this Editorial. Coverage includes the following, but is not limited to: Design (e.g. biomimicry, design for degradation/recycling/reduced toxicity…) Reagents & Feedstocks (e.g. renewables, CO2, solvents, auxiliary agents, waste utilization…) Synthesis (e.g. organic, inorganic, synthetic biology…) Catalysis (e.g. homogeneous, heterogeneous, enzyme, whole cell…) Process (e.g. process design, intensification, separations, recycling, efficiency…) Energy (e.g. renewable energy, fuels, photovoltaics, fuel cells, energy storage, energy carriers…) Applications (e.g. electronics, dyes, consumer products, coatings, pharmaceuticals, preservatives, building materials, chemicals for industry/agriculture/mining…) Impact (e.g. safety, metrics, LCA, sustainability, (eco)toxicology…) Green chemistry is, by definition, a continuously-evolving frontier. Therefore, the inclusion of a particular material or technology does not, of itself, guarantee that a paper is suitable for the journal. To be suitable, the novel advance should have the potential for reduced environmental impact relative to the state of the art. Green Chemistry does not normally deal with research associated with 'end-of-pipe' or remediation issues.











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![(4aR,5S,6R,8aS)-5-[2-(3-Furyl)ethyl]-8a-(hydroxymethyl)-5,6-dimethyl-3,4,4a,5,6,7,8,8a-octahydro-1-naphthalenecarboxylic acid structure (4aR,5S,6R,8aS)-5-[2-(3-Furyl)ethyl]-8a-(hydroxymethyl)-5,6-dimethyl-3,4,4a,5,6,7,8,8a-octahydro-1-naphthalenecarboxylic acid structure](https://static.chemtradehub.com/structs/184/18411-75-1-d4cd.webp)