Asymmetric anti-Mannich reactions in continuous flow

Literature Information

Publication Date 2013-09-20
DOI 10.1039/C3GC41444B
Impact Factor 10.182
Authors

Rafael Martín-Rapún, Sonia Sayalero


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Abstract

A polystyrene-supported, pyrrolidine-based catalyst depicting very high activity and excellent stereoselectivity in the anti-Mannich reaction of aldehydes and ketones has been developed. The very robust, immobilized catalyst has been successfully used in the implementation of a continuous flow process with short residence times (down to 6 min) for the production of highly enantioenriched anti-type Mannich adducts at the preparative scale.

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