A down-scaled fluorimetric determination of the solubility properties of drugs to minimize waste generation
Literature Information
Víctor González-Ruiz, Ana I. Olives, M. Antonia Martín
A miniaturized fluorescence assay on multi-well plates has been developed to study the solubility enhancement effect of (2-hydroxypropyl)-β-cyclodextrin on three anti-tumor alkaloids. The measurement of the fluorescence emission on a multi-well plate format has been proved to be a rapid and efficient technique to evaluate the solubility of pharmaceutical formulations of new drugs that help save time, reagents and wastes in the search for greener analytical strategies. The proposed methodology was compared with a reference HPLC solubility study and was employed to examine the enhancement of the solubility of camptothecin, luotonin A, and a synthetic derivative of the latter in the presence of (2-hydroxypropyl)-β-cyclodextrin. Considerable reductions in the time of analysis (almost 50 times faster) and the volume of organic solvents employed (close to 25 times less acetonitrile needed) were achieved. The nature of the inclusion complexes was investigated by analysis of the phase-solubility diagrams obtained by the newly developed method and was complemented with spectrofluorimetry and ESI-MS experiments. The concentrations of solubilised compounds found by both methodologies were in good agreement (R2 > 0.98). The analytical figures of merit of both methodologies were compared and the adequacy of the proposed method for the development of drug solubilisation studies was discussed.
Recommended Journals

NDT & E International

Journal of Chemical Sciences

Heteroatom Chemistry

Main Group Chemistry

Acta Metallurgica Sinica-English Letters

Critical Reviews in Solid State and Materials Sciences

Electroanalysis

Herald of the Russian Academy of Sciences

Journal of Asian Natural Products Research

Polycyclic Aromatic Compounds
Related Literature
An oligonucleotide-functionalized carbon nanotube chemiresistor for sensitive detection of mercury in saliva
Dawit N. Wordofa, Pankaj Ramnani, Thien-Toan Tran
DOI: 10.1039/C6AN00018E
Convenient and controllable preparation of a novel uniformly nitrogen doped porous graphene/Pt nanoflower material and its highly-efficient electrochemical biosensing
Shuang Ren, Huan Wang, Yufan Zhang, Yuena Sun, Lanfen Li, Hongyi Zhang, Zhihong Shi, Mingjie Li, Meng Li
DOI: 10.1039/C5AN02654G
Composition and charge state influence on the ion-neutral collision cross sections of protonated N-linked glycopeptides: an experimental and theoretical deconstruction of coulombic repulsion vs. charge solvation effects
Abby S. Gelb, Rui Lai
DOI: 10.1039/C9AN00875F
Carbon dot-based inverse opal hydrogels with photoluminescence: dual-mode sensing of solvents and metal ions
Yuhua Zhu, Jianying Wang, Xiang Zhu, Jun Wang, Lijie Zhou, Jinhua Li, Tao Mei, Jingwen Qian, Lai Wei, Xianbao Wang
DOI: 10.1039/C9AN01287G
An evaluation of monovalent, divalent, and trivalent cations as aggregating agents for surface enhanced Raman spectroscopy (SERS) analysis of synthetic cannabinoids
Thaddeus Mostowtt, Jonathan Munoz, Bruce McCord
DOI: 10.1039/C9AN01309A
Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow
Rachel E. Heap, Anna Segarra-Fas, Alasdair P. Blain, Greg M. Findlay, Matthias Trost
DOI: 10.1039/C9AN00771G
Target-controlled in situ formation of G-quadruplex DNAzyme for a sensitive visual assay of telomerase activity
Yaocai Wang, Luzhu Yang, Yanjun Wang, Wei Liu, Baoxin Li, Yan Jin
DOI: 10.1039/C9AN01271K
Portable paper sensors for the detection of heavy metals based on light transmission-improved quantification of colorimetric assays
Jing Wu, Hua Tang, Minghui He, Guangxue Chen, Junfei Tian
DOI: 10.1039/C9AN01131E
A colorimetric and fluorescent dual probe for palladium in aqueous medium and live cell imaging
Jin-wu Yan, Xiao-lin Wang, Qi-feng Tan, Pei-fen Yao, Jia-heng Tan, Lei Zhang
DOI: 10.1039/C6AN00204H
You might also like
What are the main uses of 1-(3-Aminophenyl)-3-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea (CAS: 155412-88-7)?
This compound is mainly used as an intermediate in the synthesis of antipsychoti...
How should waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 19132-12-8) be handled?
Waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 191...
What regulatory guidelines apply to 2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 2007919-81-3)?
2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 20079...
What is N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0)?
N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0) is a chemical compound with...
What is 5-Chloro-2-hydroxybenzoic acid (CAS: 321-14-2)?
5-Chloro-2-hydroxybenzoic acid, also known as 5-chlorosalicylic acid, is an arom...
What precautions should be taken when handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6)?
When handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6), it is important to u...
What are the physical and chemical properties of Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (CAS: 281655-32-1)?
Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid is a white crystalline solid ...
What are the main uses of 4-Amino-5-bromo-2-pyridinecarboxylic acid (CAS: 1363381-01-4)?
4-Amino-5-bromo-2-pyridinecarboxylic acid is primarily used as a precursor in th...
What precautions should be taken when handling (S)-tert-butyl 2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate (CAS: 1007881-98-2)?
Handling this compound should be done with personal protective equipment (PPE) i...
What precautions should be taken when handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS: 688363-73-7)?
When handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one, use prop...
Source Journal
Green Chemistry

Green Chemistry provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on, but not limited to, the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998). Green chemistry is the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry is at the frontiers of this continuously-evolving interdisciplinary science and publishes research that attempts to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. Submissions on all aspects of research relating to the endeavour are welcome. The journal publishes original and significant cutting-edge research that is likely to be of wide general appeal. To be published, work must present a significant advance in green chemistry. Papers must contain a comparison with existing methods and demonstrate advantages over those methods before publication can be considered. For more information please see this Editorial. Coverage includes the following, but is not limited to: Design (e.g. biomimicry, design for degradation/recycling/reduced toxicity…) Reagents & Feedstocks (e.g. renewables, CO2, solvents, auxiliary agents, waste utilization…) Synthesis (e.g. organic, inorganic, synthetic biology…) Catalysis (e.g. homogeneous, heterogeneous, enzyme, whole cell…) Process (e.g. process design, intensification, separations, recycling, efficiency…) Energy (e.g. renewable energy, fuels, photovoltaics, fuel cells, energy storage, energy carriers…) Applications (e.g. electronics, dyes, consumer products, coatings, pharmaceuticals, preservatives, building materials, chemicals for industry/agriculture/mining…) Impact (e.g. safety, metrics, LCA, sustainability, (eco)toxicology…) Green chemistry is, by definition, a continuously-evolving frontier. Therefore, the inclusion of a particular material or technology does not, of itself, guarantee that a paper is suitable for the journal. To be suitable, the novel advance should have the potential for reduced environmental impact relative to the state of the art. Green Chemistry does not normally deal with research associated with 'end-of-pipe' or remediation issues.
![5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amine structure 5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amine structure](https://static.chemtradehub.com/structs/122/1227210-33-4-8d64.webp)



