Comparative performance evaluation and systematic screening of solvents in a range of Grignard reactions

Literature Information

Publication Date 2013-05-03
DOI 10.1039/C3GC40702K
Impact Factor 10.182
Authors

Asha Kadam, Mylinh Nguyen, Michael Kopach, Paul Richardson, Fabrice Gallou, Zhao-Kui Wan, Wei Zhang


View Original

Abstract

The solvent effect on the Grignard reaction of benzyl, aryl and heteroaromatic substrates has been systematically evaluated based on reaction efficiency, ease of subsequent work-up, safety and greenness. 2-Methyltetrahydrofuran (2-MeTHF), which can be derived from renewable resources, had at least an equal if not a superior overall process most notably in suppressing the Wurtz coupling by-product from the benzyl Grignard reactions. It is therefore a recommended alternative solvent to Et2O and THF for the preparation of most Grignard reagents and their subsequent reactions.

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