Celecoxib cocrystal polymorphs with cyclic amides: synthons of a sulfonamide drug with carboxamide coformers

Literature Information

Publication Date 2013-09-23
DOI 10.1039/C3CE41885E
Impact Factor 3.545
Authors

Geetha Bolla, Sudhir Mittapalli, Ashwini Nangia


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Abstract

The trimorphic cocrystals of celecoxib with δ-valerolactam contain sulfonamide dimers and catemers together with carboxamide dimers, whereas the caprolactam cocrystal is sustained by a SO2N–H⋯H–NOC heterosynthon. The alternation of synthons with even–odd ring coformers offers a crystal engineering approach to sulfonamide–carboxamide cocrystals.

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