Redox-sensitive shell cross-linked PEG–polypeptide hybrid micelles for controlled drug release
Literature Information
Kang Wang, Guo-Feng Luo, Yun Liu, Cao Li, Si-Xue Cheng, Ren-Xi Zhuo, Xian-Zheng Zhang
Novel PEG–polypeptide hybrid drug carriers, poly(ethylene glycol)-b-poly(L-cysteine)-b-poly(L-phenylalanine) (PEG-PCys-PPhe) triblock copolymers, were prepared via the ring-opening polymerization of amino acid N-carboxyanhydrides. The copolymers can self-assemble to form core–shell–corona micelles in aqueous solutions. The shell of the micelles has the ability to self-cross-link (SCL) by the oxidation of thiol groups in the PCys segments. The morphology and stability of SCL micelles were characterized by TEM, DLS and SEM. The results showed the SCL micelles could hold the physical structure of micelles in severe environments. The in vitro drug release in response to GSH was also studied. It was found that the cross-linked shell could be helpful to reduce the drug loss in the extracellular environment. Under a reductive environment, the micelles would undergo the destruction of the cross-linked shell due to the cleavage of disulfide bonds, followed by accelerated drug release from the micelles. The glutathione-responsive SCL micelles could be easily uptaken by HeLa cells, suggesting these micelles might have great potential in intracellular drug delivery.
Recommended Journals

Journal of Asian Natural Products Research

Biocatalysis and Biotransformation

Topics in Catalysis

NDT & E International

Electroanalysis

Colloid Journal

Critical Reviews in Solid State and Materials Sciences

Bioorganic & Medicinal Chemistry

Acta Metallurgica Sinica-English Letters

Herald of the Russian Academy of Sciences
Related Literature
The effect of pump-2 laser on Autler–Townes splitting in photoelectron spectra of K2 molecule
Wei Guo, Xingqiang Lu, Xinlin Wang, Hongbin Yao
DOI: 10.1039/C4CP02258K
Electrochemical in battery polymerization of poly(alkylenedioxythiophene) over lithium iron phosphate for high-performance cathodes
Daniel Cíntora-Juárez, Carlos Pérez-Vicente, Shahzada Ahmad, José Luis Tirado
DOI: 10.1039/C4CP02796E
Flexible bonding between copper and nitric oxide: infrared photodissociation spectroscopy of copper nitrosyl cation complexes: [Cu(NO)n]+ (n = 1–5)
Lichen Wang, Guanjun Wang, Hui Qu, Zhen Hua Li, Mingfei Zhou
DOI: 10.1039/C4CP00557K
Theoretical investigation on structural and electronic properties of organic dye C258 on TiO2(101) surface in dye-sensitized solar cells
Ping-Ping Sun, Quan-Song Li, Li-Na Yang, Zhu-Zhu Sun, Ze-Sheng Li
DOI: 10.1039/C4CP02951H
Are hot charge transfer states the primary cause of efficient free-charge generation in polymer:fullerene organic photovoltaic devices? A kinetic Monte Carlo study
Matthew L. Jones, Reesha Dyer, Nigel Clarke, Chris Groves
DOI: 10.1039/C4CP01626B
Molecular modeling of membrane tube pearling and the effect of nanoparticle adsorption
Tongtao Yue, Xianren Zhang, Fang Huang
DOI: 10.1039/C4CP01201A
Destabilization effect of transition metal fluorides on sodium borohydride
Georgios N. Kalantzopoulos, Matylda N. Guzik, Stefano Deledda, Jiri Muller, Bjørn C. Hauback
DOI: 10.1039/C4CP02899F
Dispersion corrected DFT approaches for anharmonic vibrational frequency calculations: nucleobases and their dimers
Teresa Fornaro, Malgorzata Biczysko, Vincenzo Barone
DOI: 10.1039/C3CP54724H
You might also like
What industries use 4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine (CAS: 1015845-73-4)?
4-(4-tert-Butylphenyl)-1H-pyrazol-3-amine finds applications in various industri...
What industries use H3TATAB (CAS: 63557-10-8)?
H3TATAB is used in the pharmaceutical industry for the synthesis of certain orga...
What are the main uses of 1-Ethyl-3-fluorobenzene (CAS: 696-39-9)?
1-Ethyl-3-fluorobenzene (CAS: 696-39-9) is primarily used as a precursor in the ...
What are the main uses of 1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid (CAS: 851484-94-1)?
1-(tert-Butoxycarbonyl)-4-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid is prim...
What are the physical and chemical properties of 1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0)?
1-Cyclobutyl-4-piperidinone (CAS: 359880-05-0) is a colorless or white crystalli...
What is Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0)?
Pyridine-2,6-dicarboxylic acid mono-tert-butyl ester (CAS: 575433-76-0) is a che...
What is the market or research trend for 2,3-Difluorophenylalanine (CAS: 236754-62-4)?
The market for 2,3-Difluorophenylalanine (CAS: 236754-62-4) is growing with incr...
How is (2-Hydroxy-1-naphthyl)boronic acid (CAS: 898257-48-2) typically synthesized?
(2-Hydroxy-1-naphthyl)boronic acid can be synthesized through the reduction of 2...
What are the physical and chemical properties of tert-Butyl (5-bromo-6-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (CAS: 1315351-28-0)?
This compound is a crystalline solid with a molecular weight of approximately 52...
Are there alternatives to 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-glucopyranoside (CAS: 19833-12-6) in synthesis?
While 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl beta-D-gluc...
Source Journal
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.



![6-[2-(Trifluoromethoxy)phenyl]-2-pyridinecarboxylic acid structure 6-[2-(Trifluoromethoxy)phenyl]-2-pyridinecarboxylic acid structure](https://static.chemtradehub.com/structs/887/887983-48-4-f6ac.webp)
