Possible mechanism underlying high-pressure unfolding of proteins: formation of a short-period high-density hydration shell
Literature Information
Tomonari Sumi, Hideo Sekino
Hydration effects on high-pressure unfolding of a hydrophobic polymer chain are investigated through a multiscale simulation based on density-functional theory. The results strongly suggest the following: a thermodynamic origin for high-pressure denaturation, i.e., the decrease in volume due to the unfolding can be explained by the formation of a short-period high-density hydration shell.
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