A novel magnetic mesoporous silica packed S-shaped microfluidic reactor for online proteolysis of low-MW proteome

Literature Information

Publication Date 2011-08-24
DOI 10.1039/C1CC13969J
Impact Factor 6.222
Authors

Qianhao Min, Xiaoxia Zhang, Ren'an Wu, Hanfa Zou, Jun-Jie Zhu


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Abstract

Magnetic mesoporous silica with a magnetic cover and mesoporous core was synthesized, filled with trypsin and located in an S-shaped microfluidic reactor. High-molecular weight (MW) proteins were split to waste by fractionation, whilst low-MW proteins were retained on the chip to be digested.

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