The role of calcium in membrane condensation and spontaneous curvature variations in model lipidic systems
Literature Information
Anan Yaghmur, Barbara Sartori, Michael Rappolt
In this study, the dynamical behaviour of calcium-induced disordered to well-ordered structural transitions has been investigated by time-resolved synchrotron small-angle X-ray scattering (SAXS) in the milliseconds to seconds range. The in situ monitoring of the formed non-equilibrium self-assembled structures was achieved by the successful combination of synchrotron SAXS with stopped flow measurements. The effect of the rapid mixing of aqueous dispersions of dioleoylphosphatidyalglycerol (DOPG)/monoolein (MO) with low concentrations of Ca2+ ions is reported. Under static conditions and in the absence of Ca2+ ions, the evaluation of SAXS data for DOPG/MO aqueous dispersions prepared with three different DOPG/MO molar ratios indicates the formation of either a sponge-like L3 phase or uncorrelated bilayers. Clearly, the lipid composition plays a vital role in modulating the structural behaviour of these aqueous dispersions in the absence and also in the presence of Ca2+ ions. The rapid-mixing experiments revealed that the fast and strong interactions of Ca2+ ions with the negatively charged DOPG/MO membranes triggers the transformation from the L3 phase or the uncorrelated bilayers to the well-ordered dehydrated Lα phase or to inverted type bicontinuous cubic phases, V2, with either a symmetry of Pn3m or Im3m. Additionally, we recently reported (A. Yaghmur, P. Laggner, B. Sartori and M. Rappolt, PLoS ONE, 2008, 3, e2072) that low concentrations of Ca2+ ions trigger the formation of the inverted type hexagonal (H2) phase in DOPG/MO aqueous dispersions with a molar DOPG/MO ratio of 30/70. These are also temperature-sensitive structural transitions. Intriguingly, the strong association of Ca2+ ions with the negatively charged DOPG/MO membranes leads to fast re-organization of the two lipids and simultaneously induces fast tuning of the curvature.
Recommended Journals

Australian Journal of Chemistry

Chemistry of Natural Compounds

Anti-Corrosion Methods and Materials

Canadian Metallurgical Quarterly

Advances in Colloid and Interface Science

Journal of the American Chemical Society

Corrosion Science

Carbon

Bulletin of the Chemical Society of Japan

Cement and Concrete Research
Related Literature
Exploiting the multifunctionality of organocations in the assembly of hybrid polyoxometalate clusters and networks
Chris Ritchie, Eric M. Burkholder, De-Liang Long, David Adam, Paul Kögerler, Leroy Cronin
DOI: 10.1039/B612741J
Synthesis and characterization of a trigonal bipyramidal supramolecular cage based upon rhodium and platinum metal centers
Jered C. Garrison, Matthew J. Panzner, Paul D. Custer, D. Venkat Reddy, Peter L. Rinaldi, Claire A. Tessier, Wiley J. Youngs
DOI: 10.1039/B608991G
Separation distance dependent fluorescence enhancement of fluorescein isothiocyanate by silver nanoparticles
Daming Cheng, Qing-Hua Xu
DOI: 10.1039/B612401A
Design of a novel G-quenched molecular beacon: A simple and efficient strategy for DNA sequence analysis
Yoshio Saito, Erika Mizuno, Subhendu Sekhar Bag, Isamu Suzuka, Isao Saito
DOI: 10.1039/B709715H
Formation of cage-like hollow spherical silicavia a mesoporous structure by calcination of lysozyme–silica hybrid particles
Tatsuo Tsunoda, Akiko Kawai, Fujio Mizukami, Kengo Sakaguchi
DOI: 10.1039/B709534A
Combination of electrografting and layer-by-layer deposition: an efficient way to tailor polymer coatings of (semi)-conductors
Aurélia Charlot, Sabine Gabriel, Christophe Detrembleur, Robert Jérôme, Christine Jérôme
DOI: 10.1039/B712130J
Single-template synthesis of zeolite ZSM-5 composites with tunable mesoporosity
Jia Wang, Johan C. Groen, Wenbo Yue, Wuzong Zhou
DOI: 10.1039/B708822A
Crystallization-driven constitutional changes of dynamic polymers in response to neat/solution conditions
Cheuk-Fai Chow, Jean-Marie Lehn
DOI: 10.1039/B713413D
Reversible photochromism of a ferrocenylazobenzene monolayer controllable by a single green light source
Kosuke Namiki, Aiko Sakamoto, Masaki Murata, Shoko Kume, Hiroshi Nishihara
DOI: 10.1039/B713107K
You might also like
How is Ethyl 4-chlorothieno[2,3-b]pyridine-5-carboxylate (CAS: 59713-58-5) typically synthesized?
Ethyl 4-chlorothieno[2,3-b]pyridine-5-carboxylate (CAS: 59713-58-5) can be synth...
What regulatory guidelines apply to 5-Methyl-1H-indole-3-carbaldehyde (CAS: 52562-50-2)?
5-Methyl-1H-indole-3-carbaldehyde (CAS: 52562-50-2) is subject to various regula...
What are the physical and chemical properties of (1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)boronic acid (CAS: 223418-73-3)?
(1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)boronic acid is a white...
How should waste containing Sulfocostunolide A (CAS: 1016983-51-9) be handled?
Waste containing Sulfocostunolide A (CAS: 1016983-51-9) should be handled with c...
What precautions should be taken when handling Murraxocin (CAS: 88478-44-8)?
When handling Murraxocin (CAS: 88478-44-8), ensure proper personal protective eq...
What are the physical and chemical properties of Formvar (CAS: 63148-64-1)?
Formvar (CAS: 63148-64-1) is an alkyd resin characterized by a high molecular we...
Is (S)-4-benzyl-2-((benzyloxy)methyl)morpholine (CAS: 205242-66-6) safe?
(S)-4-benzyl-2-((benzyloxy)methyl)morpholine is generally safe when handled with...
What industries use Methyl 1-(5-bromo-2-pyrimidinyl)cyclopropanecarboxylate (CAS: 1447607-69-3)?
Methyl 1-(5-bromo-2-pyrimidinyl)cyclopropanecarboxylate (CAS: 1447607-69-3) is p...
Is 2-Methyl-1-phenyl-1-propanamine hydrochloride (CAS: 24290-47-9) safe?
2-Methyl-1-phenyl-1-propanamine hydrochloride (CAS: 24290-47-9) is generally con...
How is 3-(4-Bromophenyl)-2-methylpropanoic acid (CAS: 66735-01-1) typically synthesized?
3-(4-Bromophenyl)-2-methylpropanoic acid is synthesized through a multi-step pro...
Source Journal
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

![2-Methyl-2-propanyl 1,6-diazaspiro[3.4]octane-6-carboxylate structure 2-Methyl-2-propanyl 1,6-diazaspiro[3.4]octane-6-carboxylate structure](https://static.chemtradehub.com/structs/115/1158749-79-1-81ee.webp)


