Stereoselective Ir(iii)-catalyzed dimerization reaction of enynes: an entry to functionalized polyunsaturated and cyclic systems

Literature Information

Publication Date 2010-08-02
DOI 10.1039/C0CC00721H
Impact Factor 6.222
Authors

Mehdi Ez-Zoubir, Florent Le Boucher d'Herouville, Jack A. Brown, Virginie Ratovelomanana-Vidal, Véronique Michelet


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Abstract

The Ir(III) complex [Ir2H2I3((rac)-Binap)2]+I− efficiently promotes the selective dimerization of 1,6-, 1,7-enynes and functionalized alkynes. This catalytic process results in the formation of head-to-head isomers with (E)-stereoselectivity. Subsequent Rh-catalyzed cycloisomerization under reductive conditions led to the corresponding 1,2-dialkylidenecyclopentane derivatives.

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