Deazaflavins as mediators in light-driven cytochrome P450 catalyzed hydroxylations

Literature Information

Publication Date 2009-10-14
DOI 10.1039/B913863C
Impact Factor 6.222
Authors

Felipe E. Zilly, Andreas Taglieber, Frank Schulz, Frank Hollmann, Manfred T. Reetz


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Abstract

A light-driven deazaflavin-dependent direct enzyme regeneration system has been developed for a P450-BM3 catalyzed CH-activating hydroxylation, thereby avoiding the need for the expensive NADPH cofactor.

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