Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

Literature Information

Publication Date 2009-09-01
DOI 10.1039/B912784D
Impact Factor 6.222
Authors

John A. Karas


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Abstract

Covalently cross-linked homodimeric Aβ peptides have been prepared by solid-phase peptide synthesis by exploiting ‘site–site interactions’, and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.

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