pH-Responsive mechanised nanoparticles gated by semirotaxanes

Literature Information

Publication Date 2009-08-18
DOI 10.1039/B910431C
Impact Factor 6.222
Authors

Niveen M. Khashab, Matthew E. Belowich, Ali Trabolsi, Douglas C. Friedman, Cory Valente, Yuen Lau, Hussam A. Khatib, Jeffrey I. Zink, J. Fraser Stoddart


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Abstract

A [2]pseudorotaxane-based mechanised nanoparticle system, which operates within an aqueous acidic environment, has been prepared and characterised; this integrated system affords both water-soluble stalk and ring components in an effort to improve the biocompatibility of these promising new drug delivery vehicles.

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